Evaluation of Quality of Life at Progression in Patients with Soft Tissue Sarcoma

Sarcoma
Stacie HudgensHans Gelderblom

Abstract

Introduction. Soft Tissue Sarcoma (STS) is a rare malignancy of mesodermal tissue, with international incidence estimates between 1.8 and 5 per 100,000 per year. Understanding quality of life (QoL) and the detrimental impact of disease progression is critical for long-term care and survival. Objectives. The primary objective was to explore the relationship between disease progression and health-related quality of life (HRQoL) using data from Eisai's study (E7389-G000-309). Methods. This was a 1 : 1 randomized, open-label, multicenter, Phase 3 study comparing the efficacy and safety of eribulin versus dacarbazine in patients with advanced STS. The QoL analysis was conducted for the baseline and progression populations using the European Organization for Research and Treatment of Cancer 30-item core QoL questionnaire (EORTC QLQ-C30). Results. There were no statistical differences between the two treatment arms at baseline for any domain (p > 0.05; n = 452). Of the 399 patients who experienced disease progression (unadjusted and adjusting for histology), dacarbazine patients had significantly lower Global Health Status, Physical Functioning scores, and significantly worse Nausea and Vomiting, Insomnia, and Appetite Loss (p < 0.05)...Continue Reading

References

Dec 1, 1996·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M T King
Oct 24, 2002·American Journal of Clinical Oncology·Roberto PetrioliGuido Francini
May 30, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Daphne SchreiberAileen M Davis
Oct 28, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C WibmerR Windhager
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Eriksson

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Citations

Jun 23, 2020·Clinical Orthopaedics and Related Research·Koichi OguraJohn H Healey
Jan 25, 2020·Sarcoma·Rosa Álvarez ÁlvarezClaudia María Valverde
Mar 20, 2021·Annals of Surgical Oncology·Gilber KaskIan Barner-Rasmussen
Jul 12, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Matthias BüttnerMartin Eichler

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Methods Mentioned

BETA
X-ray

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