Evaluation of Quantitative Imaging Biomarkers in the DSS Colitis Model

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Anne BeltzerDetlef Stiller

Abstract

In humans, colonoscopy is the gold standard for the diagnosis of inflammatory changes of the colon wall. Aim of this study was the identification of less invasive imaging biomarkers in the dextran sodium sulfate (DSS) colitis model to provide additional information on transmural changes of the colon wall. Colitis was induced in C57BL/6 mice by administration of 2, 3, and 4 % DSS over a period of 5 days. Colon wall thickness was measured using magnetic resonance imaging (MRI), ultrasound (US), and x-ray computed tomography (CT), gut inflammation by positron emission tomography/CT, and mucosal changes of the colon wall by colonoscopy. Colon samples were examined histologically. MRI, CT, US, and histological data revealed increased colon wall thickness in DSS-treated mice compared to healthy controls. Elevated 2-deoxy-2[(18)F]fluoro-D-glucose uptake and colonoscopy confirmed high inflammatory load in the guts of colitis mice. The established quantitative imaging readouts offer promising perspectives to develop new compounds and to translate these methods into the clinical setting.

References

Sep 26, 1991·The New England Journal of Medicine·D K Podolsky
Feb 1, 1997·Digestive Diseases and Sciences·J W ArndtE K Pauwels
May 29, 2004·Gastroenterology·Daniel W Hommes, Sander J H van Deventer
Feb 17, 2006·Gut·E F StangeUNKNOWN European Crohn's and Colitis Organisation
Apr 5, 2007·Nature Protocols·C BeckerM F Neurath
Apr 5, 2007·Nature Protocols·Stefan WirtzMarkus F Neurath
Jan 2, 2008·Gastroenterology·Eoin P CumminsCormac T Taylor
Mar 25, 2008·ALTEX·Marcel LeistStefan Schildknecht
May 12, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Bret J SpierMark Reichelderfer
Oct 11, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Emile JubeliGillian Barratt
Feb 15, 2012·Laboratory Investigation; a Journal of Technical Methods and Pathology·Deepak K KadayakkaraEric T Ahrens
Aug 24, 2012·Lancet·Daniel C Baumgart, William J Sandborn

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Citations

Apr 3, 2018·Journal of Crohn's & Colitis·Daniel G W JohnstonSinéad C Corr
Mar 20, 2018·The International Journal of Neuropsychopharmacology·Rebecca L BarlowAnton Pekcec

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