Evaluation of Radiopharmaceutical Adverse Reaction Reports to the British Nuclear Medicine Society from 2007 to 2016

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Tracia-Gay Kennedy-DixonSobhan Vinjamuri

Abstract

This study sought to answer the calls that have been made for the European Association of Nuclear Medicine to restore its surveys of reported adverse reactions. We assessed all reports of adverse reactions to radiopharmaceuticals that were submitted to the British Nuclear Medicine Society (BNMS) online database (Radiopharmaceutical Adverse Events and Product Defects) from January 2007 to December 2016. Methods: This investigation was a pharmacovigilance-based, nonexperimental, cross-sectional study aimed at finding the prevalence of, and association between, radiopharmaceuticals and adverse reactions. Results: During the study period, there were 204 reports of radiopharmaceutical adverse reactions, of which 13 were considered invalid, primarily because of incomplete entries or because a causal relationship between the radiopharmaceutical and the adverse reaction could not be determined. Tetrofosmin (34 reports) and oxidronate (32 reports) had the highest prevalence, followed by medronate (21 reports) and then sestamibi and nanocolloid (14 reports each). Rash (84 reports), itching (46 reports), and vomiting (30 reports) were the 3 most frequently occurring adverse reactions. Most reports (96.8%) were for diagnostic radiopharmace...Continue Reading

References

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Nov 5, 2014·The Annals of Pharmacotherapy·Marie-Laure LarocheLouis Merle

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Citations

Mar 18, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Andrea SkanjetiAnthony Dhomps
Sep 29, 2019·Current Radiopharmaceuticals·Viviana FrantellizziGiuseppe De Vincentis
Sep 1, 2019·Seminars in Nuclear Medicine·Nanno SchreuderEugène van Puijenbroek
Dec 22, 2020·Nuclear Medicine Communications·Humeyra Battal, Asuman Yekta Ozer
May 9, 2021·European Journal of Hospital Pharmacy. Science and Practice·Pauline LeclercSandy Blondeel-Gomes

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