Evaluation of random urine sodium and potassium compensated by creatinine as possible alternative markers for 24 hours urinary sodium and potassium excretion

Annals of Laboratory Medicine
Hyunmin KooJeong-Ho Kim

Abstract

Sodium and potassium intake was assessed on the basis of its respective excretion levels in 24 hr urine samples. However, owing to the inconvenience of collection, we evaluated random spot urine for alternative sodium and potassium excretion markers. We included 250 patients who submitted 24 hr- and spot urine for clinical tests. However, 22 patients who showed 24 hr urine creatinine excretion levels <500 mg/day were excluded, because these samples possibly resulted from incomplete urine collection. Moreover, 24 patients were excluded because of their use of diuretics during the urine collection period. We observed significant correlations between 24 hr urine sodium excretion and both the sodium/creatinine (r=0.34, P<0.0001) and the sodium/specific gravity unit (SGU) ratios (r=0.19, P=0.007) in random urine samples. Similarly, 24 hr urine potassium excretion and both the spot urine potassium/creatinine (r=0.47, P<0.0001) and potassium/SGU ratios (r=0.28, P<0.0001) were significantly correlated. Although the estimated sodium/creatinine and potassium/creatinine ratios showed a significant correlation with 24 hr urine sodium and potassium excretion, respectively, further studies are required to develop a spot urine test for indivi...Continue Reading

References

Mar 23, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·D J NewmanA M Hiar
Nov 9, 2002·Lancet·Majid EzzatiUNKNOWN Comparative Risk Assessment Collaborating Group
May 15, 2007·The New England Journal of Medicine·Horacio J Adrogué, Nicolaos E Madias
Dec 1, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuhei KawanoUNKNOWN Working Group for Dietary Salt Reduction of the Japanese Society of Hypertension
May 4, 2010·The Journal of Clinical Hypertension·Samuel J Mann, Linda M Gerber
Jun 12, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sang-Guk LeeJeong-Ho Kim
Nov 10, 2013·Journal of the American Society of Hypertension : JASH·Horacio J Adrogué, Nicolaos E Madias

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Citations

Nov 30, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W T CaoY M Chen
Sep 14, 2018·Female Pelvic Medicine & Reconstructive Surgery·David SheynSangeeta T Mahajan
Sep 8, 2021·Molecular Medicine·Rakesh MishraAnne Davidson

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Methods Mentioned

BETA
urine collection
random urine assay

Software Mentioned

it
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