Evaluation of rapid polymyxin Nordmann Poirel test for detection of polymyxin resistance in clinical isolates of Enterobacteriaceae.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Muhammad ShoaibFaisal Hanif

Abstract

Polymyxins play a significant role against carbapenem-resistant Enterobacteriaceae (CRE). A total of 121 clinical samples yielded growth of CRE that were included in the study. Rapid Polymyxin NP test was performed on all the isolates as described by Nordmann P et al. and results were compared with broth microdilution method. Majority of the isolates were Klebsiella pneumoniae (70.2%) followed by Escherichia coli (17.4%). A total of 71 isolates were found resistant and 50 as susceptible by broth microdilution. Sensitivity and specificity of rapid polymyxin NP test were found to be 97.2% and 100%, respectively. Our study concluded that rapid polymyxin NP test is reliable and can be used as an alternative to broth microdilution in resource limited settings.

References

May 19, 2016·Emerging Infectious Diseases·Patrice NordmannLaurent Poirel
Oct 27, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C G Giske, G Kahlmeter
Nov 18, 2017·Diagnostic Microbiology and Infectious Disease·Laurent PoirelPatrice Nordmann
Dec 10, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E MatuschekG Kahlmeter
Jun 14, 2018·Diagnostic Microbiology and Infectious Disease·Aurélie JayolPatrice Nordmann
Mar 13, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Tanise Vendruscolo DalmolinAfonso Luís Barth
Aug 20, 2019·Open Forum Infectious Diseases·Zekun LiQiwen Yang
Mar 3, 2020·Chemical & Pharmaceutical Bulletin·Yasunari Otsuka
Apr 23, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Mustafa SadekPatrice Nordmann

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