Evaluation of rapid test Assure Helicobacter pylori for diagnosis of H. pylori in pediatric population

Journal of Microbiological Methods
Ana PeleritoLurdes Monteiro

Abstract

Non-invasive tests are needed to assess Helicobacter pylori infection, especially to screen a pediatric population. Assure H. pylori Rapid Test (Genelabs Diagnostics, Singapore) is an immunochromatographic assay device intended for the rapid detection of antibodies to H. pylori in human serum, plasma or whole blood. The aim of this study was to evaluate the performance of the rapid test, Assure H. pylori, in the diagnosis of H. pylori infection in children, using a Portuguese pediatric population. The study group included 130 children with age ranging from 1 to 14 years old (average age 9.2+/-3.1 years). According to the gold standard, 70 of the 130 patients studied were H. pylori positive and 60 were H. pylori negative. Using Assure H. pylori Rapid Test (Genelabs Diagnostics, Singapore), 53 sera had a positive result after 15 min (resulting in 17 false negatives) and 57 sera a negative result (resulting in 3 false positives). The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the test were 75.7%, 95.0%, 94.6% and 77.0% respectively. When a longer read time of 45 min is considered, the rapid test revealed a good performance (sensitivity 98.6% and specificity 95%) in the evaluati...Continue Reading

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Citations

Jul 21, 2009·European Journal of Pediatrics·Jeannette GuarnerSibylle Koletzko
Oct 11, 2007·Helicobacter·Gabor Veres, Ender Pehlivanoglu
Apr 17, 2016·Applied Microbiology and Biotechnology·Akbar KhalilpourAli Khademhosseini
Aug 24, 2006·Helicobacter·Petronella Mourad-Baars, Sonny Chong
May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Akbar KhalilpourRahmah Noordin
Dec 26, 2016·Applied Microbiology and Biotechnology·Akbar KhalilpourIman K Yazdi

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