Evaluation of Renal Function in Obese Children and Adolescents Using Serum Cystatin C Levels, Estimated Glomerular Filtration Rate Formulae and Proteinuria: Which is most Useful?

Journal of Clinical Research in Pediatric Endocrinology
Dilşah Önerli SalmanMerih Berberoğlu

Abstract

There is a growing interest in the relationship between obesity and renal damage. The effect of obesity on renal function in children and adolescents has not been adequately investigated. In addition, there is no complete consensus on the reliability of various renal function parameters. The primary goal of this study was to evaluate renal function in obese children and adolescents using glomerular filtration rate (GFR), cystatin C, and creatinine (Cr)-derived formulas. We also compared classical GFR measurement methods with methods based on bioimpedance analysis-derived body cell mass (BCM). We enrolled 108 obese and 46 healthy subjects aged 6-18 years. Serum cystatin C, serum Cr, 24-hour proteinuria, Cr clearance, and GFR were evaluated in both groups. Estimated GFR was measured with Cr-based, cystatin C-based, combined (cystatin C and Cr) and BCM-based formulae. Both actual and fat-free mass body surface areas (BSA) were used when required. Metabolic parameters (blood glucose, insulin, and lipids) were analyzed in the obese subjects. International Diabetes Federation criteria were used to identify metabolic syndrome (MetS). We did not detect statistically significant differences between the obese and control groups for mean ...Continue Reading

Citations

Jul 21, 2020·Environmental Pollution·Miao LiuXiaomin Zhang
Aug 26, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Niels ZiegelaschWieland Kiess
Nov 3, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Daniella MagenRam Weiss

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