Evaluation of renal function in sickle cell disease patients in Brazil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
G B Silva JuniorE F Daher

Abstract

The objective of this study was to investigate renal function in a cohort of 98 patients with sickle cell disease (SCD) followed up at a tertiary hospital in Brazil. Clinical and laboratory characteristics at the time of the most recent medical examination were analyzed. Renal function was evaluated by the estimation of glomerular filtration rate (GFR) by the criteria of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). We compared patients with normal GFR to patients with decreased GFR (<60 mL·min(-1)·(1.73 m(2))(-1)) and hyperfiltration (>120 mL·min(-1)·(1.73 m(2))(-1)). Comparison between patients according to the use of hydroxyurea and comparison of clinical and laboratory parameters according to GFR were also carried out. Average patient age was 33.8 ± 13.3 years (range 19-67 years), and 57 (58.1%) patients were females. The comparison of patients according to GFR showed that patients with decreased GFR (<60 mL·min(-1)·(1.73 m(2))(-1)) were older, had lower levels of hematocrit, hemoglobin and platelets and higher levels of urea and creatinine. Independent risk factors for decreased GFR were advanced age (OR = 21.6, P < 0.0001) and anemia (OR = 39.6, P < 0.0001). Patients with glomerular hyperfiltration tend...Continue Reading

References

Feb 11, 2005·Pediatric Blood & Cancer·Courtney D FitzhughRussell E Ware
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Dec 7, 2010·Lancet·David C ReesMark T Gladwin
Jan 11, 2011·Transactions of the Royal Society of Tropical Medicine and Hygiene·Jose P Moura NetoMarilda S Goncalves
Feb 15, 2011·Journal of Nephrology·Hélène FrancoisAntoine Durrbach
Sep 9, 2011·Annals of Hematology·Geraldo Bezerra da SilvaElizabeth De Francesco Daher

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Citations

Dec 15, 2015·Néphrologie & thérapeutique·Clément Ackoundou-N'GuessanDaze Apollinaire Gnionsahe
Jun 5, 2015·Revista brasileira de hematologia e hemoterapia·Thales Allyrio Araújo de Medeiros FernandesMaria de Fatima Sonati
Jun 18, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Arthur M LeeMark D DeBoer
Mar 30, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Cherry MammenDouglas G Matsell
May 2, 2014·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Elvira O GosmanovaPatricia E Adams-Graves
Aug 19, 2021·Revista da Associação Médica Brasileira·Lauana MaurícioDenismar Borges de Miranda

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