Evaluation of renal tubular damage in liver cirrhosis by urinary enzymes and beta-2-microglobulin excretions

European Journal of Clinical Investigation
A GattaA Ruol

Abstract

To assess the renal tubular damage in liver cirrhosis the fractional clearances of beta-2-microglobulin (B2m-fr.cl) and malate-dehydrogenase (MDH-fr.cl) were measured respectively in sixty-four and in forty-six out of seventy-nine patients with liver cirrhosis of different aetiology; furthermore the fractional excretions of gammaglutamyl-transpeptidase (fr-GGT) and of alpha-glucosidase (fr-AGL) were determined in fifty-three and in forty of them respectively. In all patients glomerular filtration rate (GFR) and renal plasma flow (RPF) were also measured. Twenty-five subjects were studied as a control group for the enzyme excretions, sixteen for B2m-fr.cl. B2m-fr.cl and MDH-fr.cl--indexes of tubular functions--on the average were normal and only slightly increased respectively in cirrhotics compared to controls. Nevertheless fr-GGT and fr-AGL--indexes of cytolysis of tubular cells--on the average were massively increased in cirrhosis compared to controls, particularly in those with reduced RPF and/or GFR. No clear relationship between the indexes of tubular damage studied and the indexes of liver function was found. Our results show that (1) A renal tubular anatomical damage was found by means of an increase in the release of en...Continue Reading

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Citations

Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A CárdenasJ Rodés
Jan 1, 1986·Journal of Hepatology·J A Solis-HerruzoA Schüller
Mar 19, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J G O'LearyW R Kim
Sep 12, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josh LevitskyMichael Abecassis
Aug 19, 2007·Clinical Chemistry·Bevin GangadharanNicole Zitzmann
Mar 27, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Sema AydogduRasit Yagci

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