PMID: 8583246Oct 1, 1995Paper

Evaluation of response to postradiation eight in one chemotherapy in childhood brain tumors

Journal of Neuro-oncology
I AyanN Bilge

Abstract

Ten children, 3 to 15 years of age with high risk primary brain tumors were treated with postradiation 'eight in one' chemotherapy; vincristine, lomustine, procarbazine, hydroxyurea, cisplatin, cytosine arabinoside, cyclophosphamide and methylprednisolone. The tumors comprised of three medulloblastomas, two primitive neuroectodermal tumors, one ependymoblastoma and four anaplastic ependymomas. Treatment involved surgery (two total resection, six subtotal and two biopsy only) followed by conventional radiotherapy (primary tumor: 50-54 Gy, whole brain: 30-45 Gy, and spinal axis: 25-36 Gy). Objective tumor response with radiotherapy was achieved in 7 of 9 patients (78%) (6/8 patients with residual tumor and one patient with complete resection but positive cerebrospinal fluid cytology). Complete response was attained in 4 of 9 patients (44%). 'Eight in one' chemotherapy was initiated four weeks after radiation and repeated at 4 weekly intervals for 5-8 courses. Postradiation 'eight in one' failed to show any additional effect on tumor responses. Median survival was 34 months (range 9-48 months) with five of ten patients alive: four in complete and one in partial remission. All the five survivors were among the patients who had achi...Continue Reading

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Citations

Oct 6, 1997·International Journal of Radiation Oncology, Biology, Physics·I AyanE Darendeliler
Jul 1, 1997·Pediatric Hematology and Oncology·E Topuz, I Ayan
Mar 18, 2004·Neurosurgery Clinics of North America·Aaron S DumontMark E Shaffrey
Sep 23, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yavuz ArasAli Nail İzgi

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