Evaluation of risk factors for prediction of outcome in fetal spectrum of atrioventricular septal defects

Congenital Heart Disease
Rima S BaderNorman H Silverman


Atrioventricular septal defects (AVSD) are very commonly diagnosed in utero. Heterotaxy/chromosomal abnormalities frequently coexist with AVSD. However, outcomes of fetal AVSD are not precisely known. We attempted to define mortality risk factors in AVSD. We retrospectively searched our database, electronic records, and echocardiograms with diagnosis of fetal AVSD from 2003 to 2012. We investigated the following risk factors: atrial situs, heart rate/rhythm, ventricular dominance/morphology, atrioventricular valve regurgitation, cardiothoracic ratio, ejection fraction, and extracardiac anomalies. Forty-five fetuses with a median gestational age of 28 weeks (17.5-37.1) were determined to have AVSD during the 10 years, of which 12 were either lost to follow-up (6) or underwent termination (6). There were 16 deaths (48%); two died in utero. Isomerism was identified in 17 of 45 (37%) fetuses (11 left atrial, 6 right atrial isomerism) and chromosomal abnormalities were identified in 12 (27%). Twenty-eight of 33 fetuses, not lost to follow-up or terminated, had extracardiac anomalies which had associated increased mortality (57% vs. 0%, P = .04). Heart block (75% vs. 43%, P = .12), left ventricular noncompaction (80% vs. 43%, P = .17...Continue Reading


Jan 1, 1990·Archives of Disease in Childhood·D PaladiniL D Allan
Mar 1, 1988·British Heart Journal·M V MachadoL D Allan
May 1, 1994·Journal of the American College of Cardiology·L D AllanN L Fagg
Jun 1, 1996·Journal of Medical Genetics·M P SplittJ Goodship
Sep 26, 1997·The Journal of Thoracic and Cardiovascular Surgery·T L GentlesG Wernovsky
Nov 5, 1999·Obstetrics and Gynecology·M F DelisleD F Farquharson
Nov 16, 1999·American Journal of Obstetrics and Gynecology·L D Allan
Aug 10, 2000·Journal of the American College of Cardiology·I C HuggonG K Sharland
Apr 2, 2002·Cardiology in the Young·Vlasta FesslovaSavina Mannarino
Nov 18, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C BergA A Baschat
Oct 29, 2005·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C SchneiderP E F Daubeney
Feb 23, 2008·Cardiology in the Young·Meryl S CohenPaul M Weinberg
Dec 6, 2007·Cardiology in the Young·Andrew M AtzUNKNOWN Investigators of the Pediatric Heart Network
Feb 24, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Petros V AnagnostopoulosMichael F Teodori
Apr 28, 2009·The Journal of Pediatrics·Mark K FriedbergLisa K Hornberger
Oct 22, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Alisa ArunamataNorman H Silverman
Aug 14, 2012·Pediatric Cardiology·Marianne P EronenErkki J Pesonen
Dec 26, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Andrea Z BeatonMary T Donofrio

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Apr 2, 2016·Pediatric Cardiology·Claudia StöllbergerJosef Finsterer
Dec 6, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Maciej SłodkiUNKNOWN International Prenatal Cardiology Collaboration Group

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