Evaluation of rotavirus vaccines in Asia--are there lessons to be learnt?

Vaccine
R MirzayevaE A S Nelson

Abstract

Rotavirus mortality is highest in the Asia-Pacific region and rotavirus vaccines could have enormous impact here. Yet, live-attenuated orally administered rotavirus vaccines have been evaluated in a small number of immunogenicity studies in some Asian countries, where the immune responses have been documented to be moderate in low-income countries with high diarrhoeal disease burden and mortality, and high in middle-/high-income countries with little reported rotavirus deaths. This review of these rotavirus clinical trials examines the results observed and attempts to draw lessons to inform decision-making, aid design of additional clinical trials and guide vaccine development by local manufacturers.

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Citations

Feb 19, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Marcelo Takahiro MituiKamruddin Ahmed
Jan 5, 2011·Immunological Reviews·Marcela F PasettiMyron M Levine
Dec 1, 2009·Expert Review of Vaccines·Miguel O'Ryan, Alexandre C Linhares
May 22, 2018·The Journal of Clinical Investigation·Cissy KityoTimothy W Schacker

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