Evaluation of Safety Guidelines on the Use of Iodinated Contrast Material: Conundrum Continued

Investigative Radiology
Estelle C NijssenJoachim E Wildberger

Abstract

Recently, safety guidelines for the use of intravascular iodinated contrast material have been updated, and the recommended threshold for giving prophylaxis to prevent contrast-induced nephropathy (CIN) has been reduced to estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m. Data on this population in the context of CIN, especially evidence for efficacy of the recommendation of prophylactic intravenous hydration, are lacking. The aim of the current study was to test implicit assumptions underlying the guideline update: (1) patients with eGFR <30 mL/min/1.73 m, as opposed to former high-risk patients with eGFR ≥30 mL/min/1.73 m, are at high risk of CIN and other unfavorable outcomes after intravascular iodinated contrast material administration; (2) prophylactic intravenous hydration mitigates this risk; and (3) the risk of administering prophylactic intravenous hydration does not outweigh the positive preventive effect. Retrospectively, data were collected from all patients with eGFR <30 mL/min/1.73 m referred for an elective procedure with intravascular iodinated contrast material administration and excluded from the AMACING trial (A MAastricht Contrast-Induced Nephropathy Guideline trial). We compared these...Continue Reading

References

Oct 26, 1990·The American Journal of Cardiology·G A Porter
Dec 31, 1997·The American Journal of Medicine·P A McCulloughW W O'Neill
Oct 8, 1998·AJR. American Journal of Roentgenology·M E TublinF N Tessler
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kevin NashSusan Hou
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Josef CoreshAndrew S Levey
Jun 12, 2003·Progress in Cardiovascular Diseases·Carlo BriguoriAntonio Colombo
Nov 18, 2004·AJR. American Journal of Roentgenology·Tadhg G Gleeson, Sudi Bulugahapitiya
Apr 13, 2005·Lancet·Kenneth F Schulz, David A Grimes
Feb 22, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Paul E de JongCarmine Zoccali
Aug 15, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Richard Solomon
Oct 3, 2008·Mayo Clinic Proceedings·Aaron M FromFurman S McDonald
Feb 24, 2009·AJR. American Journal of Roentgenology·Richard J BruceMyron A Pozniak
May 17, 2011·Journal of Vascular and Interventional Radiology : JVIR·Ronald P KarlsbergUNKNOWN Iodixanol Peripheral Computed Tomographic Angiography Study Investigator Panel
Jun 15, 2014·The American Journal of Cardiology·Mitsuru AbeTakeshi Kimura
Mar 12, 2015·The American Journal of Cardiology·Alfonso Jurado-RománJuan Tascón
Nov 14, 2017·The New England Journal of Medicine·Steven D WeisbordUNKNOWN PRESERVE Trial Group

❮ Previous
Next ❯

Citations

Apr 30, 2019·Investigative Radiology·Estelle C NijssenJoachim E Wildberger
Mar 5, 2019·Investigative Radiology·Viktor Imre ÓriásPéter Sótonyi
Feb 29, 2020·European Radiology·E C NijssenJ E Wildberger
Dec 17, 2020·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Estelle Claire NijssenJoachim E Wildberger
Nov 7, 2021·Deutsche medizinische Wochenschrift·Ulrich PeinMatthias Girndt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.