Evaluation of safety of concomitant splenectomy in living donor liver transplantation: a retrospective study

Transplant International : Official Journal of the European Society for Organ Transplantation
Amr BadawyShinji Uemoto

Abstract

In Asian countries, concomitant splenectomy in living donor liver transplantation (LDLT) is indicated to modulate the portal vein pressure in the small-sized graft to protect against small for size syndrome. While concomitant splenectomy in deceased donor liver transplantation is almost contraindicated based on Western Reports of increased mortality and morbidity rate due to septic complications, there are few studies about that in LDLT. So, we retrospectively investigated the clinical outcome of adult LDLT at Kyoto University Hospital from July 2010 to July 2016. We divided the patients (n = 164) into those with concomitant splenectomy (n = 88) and those without (n = 76). The splenectomy group showed significantly increased operative time and intraoperative blood loss (P = 0.008, P = 0.0007, respectively), and significantly higher rate of postoperative splenic vein thrombosis and cytomegalovirus infection (P = 0.03, P = 0.016, respectively). However, there were no significant differences between the two groups regarding the incidence of postoperative hemorrhage (P = 0.06), post-transplant bacteremia (P = 0.38), infection-related mortality rates (P = 0.8), acute rejection (P = 0.87), and patient and graft survival (P = 0.66, P ...Continue Reading

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Citations

May 2, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Siyuan YaoShinji Uemoto
Feb 5, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Deok-Bog MoonSu-Min Ha
Mar 5, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Siyuan YaoShinji Uemoto
Jul 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shinji HashimotoHideki Ohdan
Jan 24, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Cristiano QuintiniKoji Hashimoto
Jun 16, 2018·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Amr BadawyShinji Uemoto
Jul 10, 2019·Gastroenterology Research and Practice·Dipesh Kumar YadavTingbo Liang
Jun 23, 2018·World Journal of Gastroenterology : WJG·Xiang LanBo Li
Sep 9, 2020·Journal of Hepato-biliary-pancreatic Sciences·Toru IkegamiTakeshi Gocho
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Jul 16, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mahmoud MacshutShinji Uemoto

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