Evaluation of safety of the herbal formula Ojeok-san: acute and sub-chronic toxicity studies in rats

Journal of Ethnopharmacology
Hyekyung HaHyeun Kyoo Shin

Abstract

Ojeok-san (OJS; wuji powder in China and goshaku-san in Japan), a widely used herbal formula in traditional Korean medicine and Japanese herbal medicine (Kampo medicine), has been used to treat common cold and illnesses including fatigue and gastrointestinal disorders, but there is very little information on its safety. To provide information on the safety of OJS, we evaluated its acute and sub-chronic toxicity in rats. The single and sub-chronic toxicity of OJS was examined using male and female Sprague-Dawley rats. The rats were treated with the OJS extract orally at the highest dose level of 2000 mg/kg/day body weight. After single administration, signs of toxicity were observed every hour for the first 6h and every day for two weeks. In the sub-chronic toxicity study, OJS was administered for 13 weeks. Mortality, clinical signs, body weight changes, food and water consumption, ophthalmologic findings, urinalysis, hematological and biochemical parameters, gross findings, organ weights and histological markers were monitored during the study period. We found no mortality and no abnormality in clinical signs, body weight, and necropsy findings for any of the animals in the acute and sub-chronic toxicity study following oral ad...Continue Reading

References

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Jan 30, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Fabio Firenzuoli, Luigi Gori
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Citations

Nov 29, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Soo-Jin JeongHyeun-Kyoo Shin
Apr 19, 2015·BMC Complementary and Alternative Medicine·Soo-Jin JeongHyeun-Kyoo Shin
Jul 19, 2011·Journal of Ethnopharmacology·S YagiD Laurain-Mattar
Mar 23, 2011·Journal of Ethnopharmacology·Hyekyung HaHyeun Kyoo Shin
Aug 18, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chul Won LeeWon G An
Jan 28, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Peibo LiWeiwei Su
Jan 30, 2018·Basic & Clinical Pharmacology & Toxicology·Sang-In ParkBo-Hyung Kim
Dec 19, 2017·Experimental and Therapeutic Medicine·Zengmei LanJun Zhou

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