PMID: 9004281Nov 1, 1996Paper

Evaluation of samarium-153 and holmium-166-EDTMP in the normal baboon model

Nuclear Medicine and Biology
W K LouwA van Aswegen

Abstract

Bone-seeking radiopharmaceuticals such as ethylenediaminetetramethylene phosphonate (EDTMP) complexes of samarium-153 and holmium-166 are receiving considerable attention for therapeutic treatment of bone metastases. In this study, using the baboon experimental model, multicompartmental analysis revealed that with regard to pharmacokinetics, biodistribution, and skeletal localisation, 166Ho-EDTMP was significantly inferior to 153Sm-EDTMP and 99mTc-MDP. A more suitable 166Ho-bone-seeking agent should thus be sought for closer similarity to 153Sm-EDTMP to exploit fully the therapeutic potential of its shorter half-life and more energetic beta radiation.

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Citations

Apr 15, 2004·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Markus MitterhauserChristian Pirich
Apr 4, 2003·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Piotr GarnuszekAnna Kamińska
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Jun 1, 2021·PET Clinics·Nasim VahidfarHojjat Ahmadzadehfar

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