Evaluation of selected tropical seaweeds for in vitro anti-trichomonal activity

Journal of Ethnopharmacology
Rosa Moo-PucYolanda Freile-Pelegrín

Abstract

Human parasitic infections are a serious problem in tropical and sub-tropical developing countries. Trichomoniasis, responsible for the annual infection of 180 million people, is a common sexually transmitted disease caused by the protozoan Trichomonas vaginalis. Traditionally seaweeds have been used in folk medicine by coastal people in Asia and the Caribbean to treat parasitic infections and are a valuable source of novel anti-trichomonals. In our search for therapeutical alternatives to anti-protozoal chemotherapy, we collected a selection of 25 tropical seaweeds (12 Rhodophyta, 5 Phaeophyta and 8 Chlorophyta) from the coast of Yucatan (Mexico) in order to undertake ethnopharmacological and chemotaxonomic investigations. Organic algal extracts were tested for their anti-trichomonal properties on the growth inhibition of Trichomonas vaginalis. The cytotoxicity of seaweed extracts on mammal cell lines was also assessed. The results indicated that 44% of the seaweeds studied had high to moderate anti-trichomonal activity. Lobophora variegata and Udotea conglutinata showed the maximal anti-trichomonal activity with IC(50) values of 1.39 and 1.66microg/ml, respectively, with good selectivity. Lobophora variegata and Udotea conglu...Continue Reading

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Citations

Oct 25, 2013·Marine Drugs·Jasmine SpavieriDeniz Tasdemir
May 19, 2010·Marine Drugs·Zulema Cantillo-CiauYolanda Freile-Pelegrín
Dec 9, 2010·Marine Drugs·Adriana Oliveira Dos SantosCelso Vataru Nakamura
Jul 13, 2011·Marine Drugs·Catherine Vonthron-SénécheauAnne-Marie Rusig
Aug 17, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Rosa Moo-PucYolanda Freile-Pelegrin
Dec 4, 2012·Experimental Parasitology·Marina ScopelAlexandre J Macedo
Mar 20, 2015·Parasitology Research·Patrícia de Brum VieiraTiana Tasca
Jan 23, 2020·Marine Drugs·Dawrin Pech-PuchCarlos Jiménez
Jul 30, 2017·Environmental Science and Pollution Research International·Giovanni BenelliAkon Higuchi
Jan 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Félix Álvarez-GómezFélix L Figueroa
Sep 11, 2020·BMC Complementary Medicine and Therapies·Mendel FriedmanKirkwood M Land
Sep 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Imam FathoniTatsufumi Okino
May 9, 2012·Redox Report : Communications in Free Radical Research·Ana Mara de Oliveira e SilvaJorge Mancini-Filho
May 1, 2021·Marine Drugs·Erika M SteinEliana Nakano
May 29, 2018·Journal of Ethnopharmacology·Francisco Felipe BezerraAna Lúcia Ponte Freitas

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