Evaluation of selenium on kidney function following ischemic injury in rats; protective effects and antioxidant activity

Journal of Renal Injury Prevention
Amin HasanvandAli Kharazmkia

Abstract

Introduction: Renal dysfunction is caused by ischemia-reperfusion (I/R) injury, which is a common problem in kidney surgery or kidney transplantation. The human body consists of enormous complex antioxidant systems, which inquires adequate selenium (Se) absorption for normal physiologic function. It is known that Se has some antioxidant effects. Objectives: In the present research, effects of the Se on damages caused by I/R injury investigated. Materials and Methods: In this experimental research, four groups of rats (weighing 220±10 g) used, include control group, I/R group, healthy group treated with Se for two weeks, and I/R group with two-week Se treatment. On the test day, I/R was treated in both right and left renal arteries for 45 minutes and the reperfusion was done for 24 hours. Results: In I/R group, the amount of urea and serum creatinine (Cr) was an injury indicator of the kidney cells which showed a significant increase compared with the control group. When the treatment with Se significantly reduced these indicators, glutathione (GSH) enzyme levels reduced significantly in the second group and the enzyme levels increased due to Se treatment in the fourth group. Furthermore, malondialdehyde (MDA) enzyme levels incr...Continue Reading

Citations

Apr 19, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Georgios KyriakopoulosConstantinos E Simopoulos
Oct 27, 2017·International Journal of Molecular Sciences·Bozena HosnedlovaRene Kizek
Jan 1, 2018·Biological Trace Element Research·Sibel GunesRuhi Uyar
Jul 21, 2020·Oxidative Medicine and Cellular Longevity·Afsaneh NematiMohammadreza Gholami
Aug 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aneta Ostróżka-CieślikFlorian Ryszka
Apr 29, 2020·Food & Function·María Luisa OjedaOlimpia Carreras
Jan 3, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·F NogalesO Carreras
Aug 23, 2021·Environmental Science and Pollution Research International·Ibrahim M AlhazzaMohamed Sheikh

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