Evaluation of self-report adherence measures and their associations with detectable viral load among people living with HIV (PLHIV) in China

PloS One
Wendi DaZhiyong Shen

Abstract

Self-report antiretroviral therapy (ART) adherence has been consistently associated with clinical outcomes. This study aims to compare the accuracy of self-report ART adherence measures with varying recall timeframes or item contents to predict virological response. Data from a cross-sectional study among 2146 participants on ART in Guangxi, China were used. Detectable viral load was defined as viral load > 50 copies/ml. Adherence was measured using the number of days on which all doses were taken in the past month (i.e., the "one-month days taken" measure), the number of days on which any dose was missed in the past month (i.e., the "one-month days missed" measure), missed doses over the past 3 days, and missed days over the past weekend. Each adherence measure was dichotomized at an empirically determined cut-off to determine poor vs. good adherence. Accuracy of using each dichotomized adherence measure to predict detectable viral load was assessed by sensitivity, specificity, and the area under the receiver-operating characteristic (AUROC) curve. Logistic regressions were used to calculate the association between poor adherence and detectable viral load. All four measures had sensitivity below 10.0%, specificity above 90.0%,...Continue Reading

References

Aug 5, 2005·The New England Journal of Medicine·Lars Osterberg, Terrence Blaschke
Feb 23, 2008·AIDS Care·S MannheimerUNKNOWN Terry Beirn Community Program for Clinical Research on AIDS
Dec 25, 2010·AIDS and Behavior·Karina M BergJulia H Arnsten
Mar 13, 2012·AIDS and Behavior·Ann Bartley WilliamsJulie A Womack
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