Evaluation of semen quality, endocrine profile and hypothalamus-pituitary-testis axis in male patients with homozygous beta-thalassemia major

The Journal of Urology
M R Safarinejad

Abstract

The endocrine profile, hypothalamus-pituitary-testis axis and semen quality were evaluated in male patients with homozygous beta-thalassemia major. A total of 168 male patients 18 years or older with homozygous beta-thalassemia major were enrolled in the study and 84 healthy age matched male volunteers served as controls. All subjects provided a medical history and underwent physical examination and routine semen analysis. Two blood samples were drawn from each participant at 20-minute intervals to determine the resting levels of certain hormones, including luteinizing hormone, follicle-stimulating hormone, prolactin, testosterone, estradiol, insulin-like growth factor-1 and insulin like growth factor binding protein-3. The hypothalamus-pituitary-testis axis was also assessed using the luteinizing hormone-releasing hormone test. The prevalence of hypogonadotropic hypogonadism was 76.2% (128 patients). Of the studied patients with homozygous beta-thalassemia major 75 (44.6%) were short. Compared with normal controls the patients with homozygous beta-thalassemia major had lower serum luteinizing hormone, follicle-stimulating hormone, insulin-like growth factor-1, insulin-like growth factor-1 binding protein-3 and testosterone. In...Continue Reading

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Citations

May 7, 2010·Journal of Pediatric Hematology/oncology·Mohammad Reza Safarinejad
Nov 15, 2011·AJNR. American Journal of Neuroradiology·L J NoetzliJ C Wood
Mar 14, 2018·Nature Reviews. Urology·Francesco Lotti, Mario Maggi
Mar 9, 2018·Endocrine Connections·Mikkel AndreassenNiels Jørgensen
Jun 5, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Preamrudee PoomthavornLa-Or Chailurkit
Dec 14, 2018·Experimental and Therapeutic Medicine·Suleyman YesilMustafa Arslan
Jun 6, 2015·American Journal of Hematology·Sylvia T SingerJames F Smith
Jun 25, 2021·Annals of Global Health·Morteza Arab-ZozaniEbrahim Miri-Moghaddam

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