Evaluation of serum aminoterminal procollagen type III propeptide as an index of portal hypertension and esophageal varices in chronic liver diseases

Clinica Chimica Acta; International Journal of Clinical Chemistry
A M GressnerJ Kropf

Abstract

The concentration of the aminoterminal propeptide of type III procollagen (P-III-P) was determined in serum of cubital vein and hepatic vein of patients with various types of chronic liver diseases (n = 111) and correlated with the portal venous pressure and with the degree of esophageal varices. The P-III-P level in all chronic liver diseases was correlated (rS 0.542, p less than 0.001) with the portal venous pressure, but in liver fibrotic subjects (n = 29) this correlation (rS 0.310) was not significant, in liver cirrhosis (n = 30) the respective correlation was found to be weak (rS 0.333, p less than 0.05) and similar to that in patients with unspecified chronic liver diseases (n = 52) (rS 0.425, p less than 0.01). Sensitivity and specificity of P-III-P at a cut-off concentration of 12 ng/ml for portal hypertension (portal vein pressure 5 mm Hg) are 0.93 and 0.42, respectively, the diagnostic efficiency is 0.67. Predictive values at the same cut-off level of P-III-P and an assumed prevalence of portal hypertension of 50% are 0.62 and 0.85 for the positive and negative test result, respectively. The level of P-III-P is not related to the degree of esophageal varices. The mean P-III-P concentration in the hepatic vein was fou...Continue Reading

References

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Citations

Apr 17, 2012·International Journal of Hepatology·Kara RyeJan Freeman
Jan 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dominique ThabutDidier Lebrec
Jun 1, 1991·Clinical Biochemistry·M Plebani, A Burlina
Jan 7, 2015·World Journal of Gastroenterology : WJG·Maurizio SoresiGiuseppe Montalto

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