Evaluation of serum and urinary myeloid related protein-14 as a marker for early detection of prostate cancer

The Journal of Urology
Heiko MüllerHermann Brenner

Abstract

Early detection of prostate cancer by prostate specific antigen testing is subject to ongoing controversy. Thus, practical tests to improve or replace prostate specific antigen would be highly desirable. In diagnostic studies promising results were shown for myeloid related protein-14 in serum and urine. However, confirmation in longitudinal population based studies is needed. Incident prostate cancer cases (32) and controls (74) matched by age were identified during a 2-year followup of a longitudinal study. The group of cases was further complemented by a sample of 24 prostate cancer cases recruited before initiation of treatment from a clinical study. A commercially available test was used to analyze serum and urinary myeloid related protein-14 in blinded fashion. In contrast to prostate specific antigen, serum and urinary myeloid related protein-14 could not significantly discriminate between prostate cancer cases and controls. In our study neither serum nor urinary myeloid related protein-14 proved suitable to distinguish prostate cancer cases from controls. Overall myeloid related protein-14 performed much worse than prostate specific antigen and it does not seem useful to reduce false-positive findings of prostate specif...Continue Reading

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Citations

Feb 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Karen S SfanosWilliam B Isaacs
Mar 26, 2009·Current Opinion in Urology·George BotchorishviliHans Lilja
Oct 23, 2015·Expert Review of Molecular Diagnostics·Maria FrantziHarald Mischak
Jan 1, 2010·Expert Opinion on Medical Diagnostics·Joanna M Hunter, Eustache Paramithiotis
Dec 7, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·X DurandA De la Taille
Apr 26, 2012·Proteomics. Clinical Applications·Wei WuMaxey C M Chung
Jul 31, 2016·Acta Physiologica·E V SchrezenmeierK M Schmidt-Ott
Jun 14, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·O YasarF A Turegun
Jan 12, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Kianoush KashaniClaudio Ronco
Jan 13, 2010·Nature Reviews. Urology·Guillaume Ploussard, Alexandre de la Taille
Nov 18, 2011·The Journal of Urology·Tilman TodenhöferChristian Schwentner
Jan 19, 2019·Prostate Cancer and Prostatic Diseases·Jillian N EskraJun Luo

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