PMID: 6539702May 1, 1984Paper

Evaluation of serum fucosyltransferases in malignancy

European Journal of Cancer & Clinical Oncology
R Kuzmits, P Aiginger

Abstract

Incorporation of [14C]-fucose into the endogenous acceptor of serum and into the exogenous acceptors desialofetuin (alpha 2-fucosyltransferase) and desialodegalactofetuin (alpha 3-fucosyltransferase) was determined in controls and in patients with various malignant diseases. Seventy-five percent of untreated cancer patients showed increased incorporation rates into the endogenous acceptor of serum. Increased rates of alpha 2-fucosyltransferase activity were observed in 67% and of alpha 3-fucosyltransferase activity in 49% of patients respectively. After successful chemotherapy a fall of fucosyltransferase activities could be observed and in non-responding patients an increase of fucosyltransferase activities during and after therapy was found. Determination of fucosyltransferase activities might provide an additional biological marker in monitoring cancer patients.

References

Jul 1, 1978·Journal of the National Cancer Institute·S K Chatterjee, U Kim
Jan 15, 1976·The Biochemical Journal·C H BauerW G Reutter
May 23, 1976·Biochemical and Biophysical Research Communications·C BauerW Reutter
Jun 1, 1973·Archives of Biochemistry and Biophysics·J R Munro, H Schachter
Oct 1, 1972·European Journal of Biochemistry·H Schenkel-BrunnerW M Watkins
Nov 1, 1968·Archives of Biochemistry and Biophysics·H B BosmannE H Eylar
Aug 1, 1969·The Journal of Clinical Investigation·E F GrollmanV Ginsburg

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