Evaluation of serum level of sex hormones in women with frontal fibrosing alopecia in comparison to healthy controls.

Dermatologic Therapy
Soheila NasiriNikoo Mozafari

Abstract

The pathogenesis of frontal fibrosing alopecia (FFA) is still unknown while hormonal factors have been postulated to play a role. There is scarce evidence with divergent results on the role of sex hormones in FFA. To evaluate the possible association between sex hormone levels and FFA, this study included 30 female cases of FFA and 34 healthy controls. Serum free testosterone, dehydroepiandrosterone sulfate (DHEAS), Luteinizing hormone (LH), follicle-stimulating hormone (FSH), 17-OH progesterone, androstenedione, and prolactin levels were measured in all subjects. Median and interquartile ranges of DHEAS and androstenedione were 79.26 (52.91-195.50) and 1.41 (0.90-2.29) in patients and 152.34 (81.72-218.63) and 2.31 (1.54-2.84) in healthy controls, respectively. The serum levels of DHEAS and androstenedione were significantly lower in FFA patients in comparison with healthy controls (P-value = .038 and .012, respectively). There were no significant differences in serum levels of free testosterone, LH, FSH, 17-OH progesterone, and prolactin between the FFA group and the control group The lower serum levels of DHEAS and androstenedione in FFA patients compared to controls is supporting a new growing concept of the low androgen le...Continue Reading

References

Nov 13, 2012·The European Respiratory Journal·Criselda Mendoza-MillaMoisés Selman
Feb 11, 2014·Journal of the American Academy of Dermatology·Sergio Vañó-GalvánFrancisco M Camacho
Feb 24, 2016·Indian Journal of Endocrinology and Metabolism·Sanjay SaranPankaj Agrawal
Feb 26, 2016·International Journal of Dermatology·Maryam YousefiShima Younespour
Jan 17, 2017·Journal of the American Academy of Dermatology·Geraldine Cheyana RanasingheWilma F Bergfeld
Jan 19, 2017·Anais Brasileiros De Dermatologia·Neide Kalil Gaspar
Sep 25, 2017·Clinical and Experimental Dermatology·C BernárdezF M Camacho
Mar 11, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·A Murad, W Bergfeld
May 15, 2018·Frontiers in Immunology·Melanie R Gubbels Bupp, Trine N Jorgensen
Nov 10, 2018·Skin Appendage Disorders·Diego Buendía-CastañoSergio Vañó-Galván
Jan 20, 2019·American Journal of Clinical Dermatology·Matilde Iorizzo, Antonella Tosti
Apr 19, 2019·International Journal of Women's Dermatology·Soheil TavakolpourMaryam Daneshpazhooh
Jun 19, 2020·International Journal of Trichology·Mohammad SasanniaFatemeh Sari Aslani

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Citations

May 1, 2021·Journal of Clinical Medicine·María Librada Porriño-BustamanteSalvador Arias-Santiago

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