Evaluation of serum SLCO1B1 levels and genetic variants of SLCO1B1 rs4149056 and rs2306283 in patients with early and exudative age-related macular degeneration

Gene
Rasa LiutkevicieneLoresa Kriauciuniene

Abstract

To determine SLCO1B1 rs4149056 and rs2306283 gene polymorphisms and SLCO1B1 serum levels in patients with early and exudative age-related macular degeneration. The study enrolled 206 patients with exudative AMD, 253 patients with early AMD and 301 control subjects. DNA was extracted from peripheral venous blood leukocytes using commercial kits. Genotyping of SLCO1B1 rs4149056 and rs2306283 was carried out using a real-time polymerase chain reaction (RT-PCR) method. Serum SLCO1B1 levels were measured using SLCO1B1 ELISA kit. We found statistically significant differences in genotype (T/T, T/C and C/C) distribution of SLCO1B1 rs4149056 variant between the patients with exudative AMD and control group (52.4%, 47.6% and 0% vs. 64.8%, 31.6% and 13.7%, respectively, p < 0.001). Univariate binary logistic regression analysis showed that age was a risk factor for exudative AMD development. Also, T/C variant was associated with 1.9-fold increased Odds ratio of exudative AMD development under a codominant model (OR = 1.863; 95% CI: 1.290;2.689; p < 0.001). The results remained of the same statistical significance after multivariate analysis. On the other hand, C allele was associated with 1.6-fold increased odds ratio of exudative AMD de...Continue Reading

References

Apr 3, 2004·American Journal of Ophthalmology·Redmer van LeeuwenPaulus T V M de Jong
Apr 14, 2004·Archives of Ophthalmology·Marco A Zarbin
Jul 6, 2004·Ophthalmology·Sandra C TomanyPaulus T V M De Jong
Mar 10, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Jörg KönigMartin F Fromm
Oct 6, 2006·The New England Journal of Medicine·Paulus T V M de Jong
Nov 17, 2006·Pharmacogenetics and Genomics·Marja K PasanenMikko Niemi
May 3, 2007·Clinical Pharmacology and Therapeutics·M K PasanenM Niemi
Dec 18, 2007·Clinical and Experimental Immunology·S Rodríguez de Córdoba, E Goicoechea de Jorge
Mar 11, 2008·Investigative Ophthalmology & Visual Science·Martin RudolfChristine A Curcio
Jun 17, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Cuiping ChenSonia M de Morais
Jul 25, 2008·The New England Journal of Medicine·UNKNOWN SEARCH Collaborative GroupR Collins
Oct 17, 2009·Journal of the American College of Cardiology·Deepak VooraGeoffrey S Ginsburg
Dec 3, 2009·Pharmacogenetics and Genomics·Connie OshiroRuss Altman
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Benjamin M NealeJohanna M Seddon
Mar 10, 2011·Pharmacogenetics and Genomics·Kristin D MarcianteBruce M Psaty
Sep 20, 2011·European Journal of Clinical Pharmacology·Paulo Caleb Junior Lima SantosAlexandre Costa Pereira
Dec 6, 2011·Basic & Clinical Pharmacology & Toxicology·Vinicius de A SorticaMara H Hutz
Apr 17, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Vinicius A SorticaMara H Hutz
May 24, 2012·Clinical Pharmacology and Therapeutics·R A WilkeUNKNOWN Clinical Pharmacogenomics Implementation Consortium (CPIC)
Mar 20, 2013·Molecular Aspects of Medicine·Bruno Hagenbuch, Bruno Stieger
May 28, 2013·American Heart Journal·Jacqueline S DanikPaul M Ridker
Feb 14, 2014·Revista médica de Chile·Luis MéndezJuan F Miquel
Sep 4, 2015·International Journal of Molecular Sciences·Yalena PradoLuis A Salazar

❮ Previous
Next ❯

Citations

Jun 23, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Rene de BeerPrashilla Soma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.