Evaluation of Sesbania grandiflora for antiurolithiatic and antioxidant properties.

Journal of Natural Medicines
Sujatha DoddolaKoganti V S R G Prasad

Abstract

In the indigenous system of medicine in India, the plant Sesbania grandiflora is claimed to be useful for various ailments, and one such use is for the treatment of renal calculi. The major purpose of this study is to investigate the potential of S. grandiflora in the treatment of renal calculi. The leaf juice of S. grandiflora was evaluated for median lethal dose, gross behavioral changes, antiurolithiatic and antioxidant activities. The antiurolithiatic activity was evaluated by a calculi-producing diet model, using gentamicin (subcutaneously) and 5% ammonium oxalate in rat feed to induce calcium oxalate-type stones. The parameters monitored in the present study are calcium and oxalate deposition in the kidney, kidney weights, urinary excretion of calcium and oxalate. The in vivo antioxidant parameters lipid peroxidation, glutathione reductase and catalase were monitored. The plant juice was also evaluated for scavenging of nitric oxide and 2-diphenyl-2-picryl hydrazyl free radicals. The leaf juice of S. grandiflora was safe orally and exhibited no gross behavioral changes except for an increase in urination. The leaf juice of S. grandiflora showed significant antiurolithiatic activity against calcium oxalate-type stones and ...Continue Reading

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Citations

Mar 13, 2014·Journal of Analytical Methods in Chemistry·A S ZarenaR Vineeth
Jun 21, 2014·BioMed Research International·Sankar PajaniradjeRukkumani Rajagopalan
Sep 7, 2011·Experimental Biology and Medicine·Emilia Amengual-CladeraIsabel Lladó
Jan 1, 2012·Pharmaceuticals·Noviany HasanAnis Safirah Mohd Zahariluddin
Feb 1, 2012·Asian Pacific Journal of Tropical Biomedicine·Saravana Kumar ArthanariDe Clercq
Jan 27, 2015·Metabolic Brain Disease·Thiyagarajan RameshVavamohaideen Hazeena Begum
Sep 14, 2014·Metabolic Brain Disease·Thiyagarajan RameshVavamohaideen Hazeena Begum
Jan 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mya Mu AyeChabaco Armijos
Jun 15, 2021·Saudi Journal of Biological Sciences·Muhammad AfzalAmeeduzzafar Zafar
Jan 4, 2022·Journal of Food Biochemistry·Ganesamoorthy JanarnyKatugampalage Don Prasanna Priyantha Gunathilake

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