Evaluation of short chain chlorinated paraffins in human milk and their intake by infants in Hebei Province, China

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Lixin YangJianbo Zhang

Abstract

Short-chain chlorinated paraffins (SCCPs) have drawn increasing interest worldwide since they were included in the list of controlled persistent organic pollutants in Annex A of the Stockholm Convention in 2017, and the potential health risk they pose to humans must be evaluated. In this study, 86 human milk samples were collected from 55 healthy Chinese mothers living in the Shijiazhuang region of Northern China in 2014-2015. Advanced online gel permeation chromatography-gas-chromatography-coupled mass spectrometry with negative-ion chemical ionisation was used to quantify the SCCPs in the samples. The estimated mean level of SCCPs was 2.51 μg g-1 lipid weight (range 0.21-16.12). The SCCP concentration correlated positively with the mother's bodyweight at the end of pregnancy (P < 0.05). The mean SCCP intake by infants via breast milk was 13.0 μg kg-1 day-1 at 1 month, 7.1 μg kg-1 day-1 at 3 months, and 2.5 μg kg-1 day-1 at 6 months after birth. This study provides initial data on the levels of SCCPs in human milk in a chlorinated-paraffin-manufacturing area in China, and indicates a high health risk for infants.

References

Nov 5, 2003·Environmental Science & Technology·C H MarvinD C G Muir
Jun 28, 2005·Environment International·Gareth O ThomasKevin C Jones
Jan 14, 2010·Archives of Toxicology·Gayathri D WarnasuriyaClifford R Elcombe
Jul 13, 2011·Environmental Science & Technology·Kouji H HaradaAkio Koizumi
May 19, 2012·Environmental Science & Technology·Bo YuanGuibin Jiang

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Citations

Sep 3, 2020·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Elsa Nielsen
Apr 3, 2021·Environmental Research·Lixin YangKaoqi Lian
Feb 27, 2020·Environmental Science & Technology·Yihui ZhouÅke Bergman
Sep 4, 2021·Environmental Science and Pollution Research International·Vhodaho Nevondo, Okechukwu Jonathan Okonkwo

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Methods Mentioned

BETA
column chromatography

Software Mentioned

SPSS Statistics

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