Evaluation of silymarin as a promising radioprotector

Zeitschrift Für Naturforschung. C, a Journal of Biosciences
Manish AdhikariRakesh K Sharma

Abstract

Silymarin, a purified extract of seeds of Silybum marianum L. and well known for its hepatoprotective abilities, has been evaluated for inherent utility as a radioprotective agent. A fraction (INM-7035) was authenticated by characterizing the percentage composition of silybin A and B (39.9% and 57.4%). Free radical scavenging activities of INM-7035 against superoxide radicals (>68%), hydroxyl radicals (>33.75%), DPPH (67.2%), and ABTS (32.4%) were also evaluated. The fraction chelated (>30%) ferrous ions, thereby able to restrict amplification. INM-7035 exhibited >50% peroxyl radical scavenging activity in the lipid phase along with dose-dependent (R2 = 0.990) reducing power in the aqueous phase. Radiation-induced free radical flux can lead to disruption of biomolecules like membrane lipids. INM-7035 completely inhibited lipid peroxidative stress in case of membranes against supralethal radiation stress in the liposomal system. The ability of INM-7035 to modulate the levels of NF-kappaB, indicated its inherent potential as a radioprotective bioactive constituent.

Citations

Oct 20, 2012·International Journal of Radiation Biology·Manish AdhikariRajesh Arora
Apr 13, 2011·Experimental & Molecular Medicine·Wanyeon KimBuHyun Youn
Jan 20, 2018·Indian Journal of Dermatology, Venereology and Leprology·Konchok DorjayMohammad Adil
Dec 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qinqi WangFengru Tang
Jun 7, 2011·International Journal of Surgery·Jamsheer J TalatiRichard David Rosin

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