PMID: 6107159Sep 27, 1980Paper

Evaluation of single-dose hypnotic treatment before elective operation

British Medical Journal
M R KeighleyR J Gammon

Abstract

A prospective randomised double-blind controlled trial was carried out to evaluate the place of a single dose of triazolam, flurazepam, and placebo on the evening before an elective operation in 96 patients. Features of sleep were recorded by patients and nurses on questionnaires. Onset of sleep was delayed and duration of sleep reduced in two-thirds of patients allocated placebo compared with their normal sleep pattern. Two-thirds of these patients also complained of waking more than twice during the night. Both hypnotics significantly improved the duration and time of onset of sleep and reduced the frequency of wakening when compared with the placebo. Patients who took triazolam, however, fell asleep faster and woke less often than those who took flurazepam. Furthermore, triazolam appeared to have advantages over flurazepam before surgery. Thus giving a single dose of a hypnotic on the night before an elective operation improves the patient's sleep, and greater benefit was derived from triazolam than flurazepam.

References

Nov 1, 1979·American Journal of Surgery·N B Kavey, K Z Ahshuler
Feb 1, 1977·The American Journal of Cardiology·W C Orr, M L Stahl
Apr 20, 1979·JAMA : the Journal of the American Medical Association·A KalesC R Soldatos
May 1, 1974·The British Journal of Surgery·M W JohnsH A Dudley
Dec 1, 1973·Journal of Pharmaceutical Sciences·S A KaplanL Weissman
Mar 1, 1980·British Journal of Clinical Pharmacology·A N Nicholson

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Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·E Wickstrøm, C Allgulander
Mar 1, 1997·Journal of Clinical Anesthesia·P J MorganJ Le Lorier
Dec 1, 1988·International Journal of Oral and Maxillofacial Surgery·N H LuykJ Sacks
Nov 1, 1993·The Journal of the American Dental Association·C W BertholdR A Dionne

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