Evaluation of single nucleotide polymorphisms of pvmdr1 and microsatellite genotype in Plasmodium vivax isolates from Republic of Korea military personnel

Malaria Journal
Dong-Il ChungYoun-Kyoung Goo

Abstract

Chloroquine has been administered to the soldiers of the Republic of Korea as prophylaxis against vivax malaria. Recent increase in the number of chloroquine-resistant parasites has raised concern over the chemoprophylaxis and treatment of vivax malaria. To monitor the development of chloroquine-resistant parasites in the Republic of Korea, analyses of single nucleotide polymorphisms (SNPs) of pvmdr1 and microsatellite markers were performed using samples collected from 55 South Korean soldiers infected with Plasmodium vivax. Four SNPs, F1076L, T529, E1233, and S1358, were identified. Among these, S1358 was detected for the first time in Korea. The microsatellite-based study revealed higher genetic diversity in samples collected in 2012 than in 2011. Taken together, the results indicate that P. vivax with a newly identified SNP of pvmdr1 has been introduced into the Korean P. vivax population. Therefore, continuous monitoring for chloroquine-resistant parasites is required for controlling vivax malaria in the Republic of Korea.

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Citations

Feb 27, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Adel SpotinMostafa Farmani
Jan 12, 2019·The Korean Journal of Parasitology·Young Yil BahkTong-Soo Kim

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Methods Mentioned

BETA
PCR
electrophoresis
PCRs

Software Mentioned

Clustal Omega
LIAN
GeneMapper
eBURST

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