Evaluation of single nucleotide polymorphisms (SNPs) in the p53 binding protein 1 (TP53BP1) gene in breast cancer patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT).

International Journal of Radiation Oncology, Biology, Physics
Bruce G HafftyKim M Hirsfield

Abstract

TP53BP1 is a key component of radiation-induced deoxyribonucleic acid damage repair. The purpose of this study was to evaluate the significance of a known common single nucleotide polymorphism in this gene (rs560191) in patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT). The population consisted of 176 premenopausal women treated with BCS + RT (median follow-up, 12 years). Genomic deoxyribonucleic acid was processed by use of TaqMan assays. Each allele for rs560191 was either C or G, so each patient was therefore classified as CC, CG, or GG. Patients were grouped as GG if they were homozygous for the variant G allele or CC-CG if they carried at least one copy of the common C allele (CC or CG). Of the 176 women, 124 (71%) were CC-CG and 52 (29%) were GG. The mean age was 44 years for GG vs. 38 years for CC-CG (p < 0.001). GG was more common in African-American women than white women (69% vs. 13%, p < 0.001) and more commonly estrogen receptor negative (70% vs. 49%, p = 0.02). There were no significant correlations of rs560191 with other critical variables. Despite the fact that GG patients were older, the 10-year rate of local relapses was higher (22% for GG vs. 12% for CC-CG, p = 0.04). This...Continue Reading

References

Oct 1, 1990·International Journal of Radiation Oncology, Biology, Physics·B G HafftyJ J Fischer
Jan 1, 1988·International Journal of Radiation Oncology, Biology, Physics·A RechtJ R Harris
Aug 30, 1994·International Journal of Radiation Oncology, Biology, Physics·B L FowbleJ H Glick
Jan 17, 2002·The New England Journal of Medicine·H BartelinkUNKNOWN European Organization for Research and Treatment of Cancer Radiotherapy and Breast Cancer Groups
Feb 19, 2002·International Journal of Radiation Oncology, Biology, Physics·Christopher M IannuzziBarry S Rosenstein
May 4, 2002·Lancet·Bruce G HafftyMayra Alvarez-Franco
Apr 28, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C SeynaeveC T M Brekelmans
Jun 23, 2005·Cell Cycle·Tibor RauchXingzhi Xu
Mar 7, 2006·Cancer Letters·Katrin RapakkoRobert Winqvist
Apr 26, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lori J PierceBarbara L Weber
Jun 6, 2006·International Journal of Radiation Oncology, Biology, Physics·Alice Y HoBarry S Rosenstein
Jul 27, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kuniyoshi IwabuchiTakayasu Date
Nov 23, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce G HafftyDeborah Toppmeyer
Feb 15, 2007·International Journal of Medical Sciences·Chikako Kiyohara, Kouichi Yoshimasu
Oct 19, 2007·Cancer Research·Zuben E SaunaMichael M Gottesman
Apr 11, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Zhonghua WangXichun Hu
Sep 10, 2008·BMC Medicine·Patrick Tan
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anne M SchultheisHeinz-Josef Lenz
Dec 19, 2008·European Journal of Human Genetics : EJHG·Tim RippergerBrigitte Schlegelberger
Feb 7, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G F LehnerdtH S Bachmann
Feb 10, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Fei MaDongxin Lin
Feb 14, 2009·Human Genetics·Evgeny N Imyanitov
Apr 9, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·R L MilneN Malats
May 12, 2009·Experimental and Molecular Pathology·Renata KrupaJanusz Blasiak
May 21, 2009·Annual Review of Genomics and Human Genetics·Jiannis Ragoussis
Oct 8, 2009·JAMA : the Journal of the American Medical Association·Werner SchrothHiltrud Brauch

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