Evaluation of some water-miscible organic solvents for spray-drying enzymes and carbohydrates

Drug Development and Industrial Pharmacy
Anke Sass, Geoffrey Lee

Abstract

The spray-drying behaviour of 16 water-miscible organic solvents on a bench-scale machine (Büchi B290 with inert loop) was determined under mild-to-moderate process conditions, namely inlet gas temperature of 130 °C and liquid feed flow rate of ≤3 mL/min. The solvents with boiling points below the inlet gas temperature could be fully dried (Group 1 solvents). The two exceptions were DMSO and DMF which despite their higher boiling points could be fully dried. The remaining solvents with boiling points above the inlet gas temperature were not fully dried during passage through the spray-dryer (Group 2 solvents). Trypsin and lysozyme when spray-dried from Group 1 solvent binary mixtures with water showed similar inactivation and residual water content, independent of solvent. The level of residual solvent was, however, strongly dependent on solvent. Trehalose (20%) and mannitol (10%) could be spray-dried from DMSO/water binary mixtures, but the amorphous disaccharide required higher inlet gas temperature. Trehalose/trypsin and mannitol/trypsin formulations showed differing degrees of protection against enzyme inactivation when spray-dried from Group 1 solvent binary mixtures with water. In all solvents the mannitol protected as we...Continue Reading

References

Jun 1, 1994·The Journal of Pharmacy and Pharmacology·J BroadheadC T Rhodes
Jan 1, 1994·Chemical & Pharmaceutical Bulletin·K IzutsuT Terao
Apr 1, 1999·Biotechnology and Bioengineering·Y F MaaC C Hsu
Oct 16, 1999·International Journal of Pharmaceutics·A Millqvist-FurebyB Bergenståhl
Mar 29, 2000·Journal of Pharmaceutical Sciences·A BurgerH Stöttner
Mar 19, 2002·International Journal of Pharmaceutics·Kristina StåhlKjell Bäckström
Apr 10, 2002·Analytical and Bioanalytical Chemistry·Rudolf TuckermannBernd Neidhart
Jun 5, 1994·Biotechnology and Bioengineering·J T ChinA M Klibanov
Nov 11, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·F SansoneP Russo
Feb 25, 2009·Expert Opinion on Drug Delivery·Ambikanandan MisraMahavir Chougule
Jun 9, 2009·International Journal of Pharmaceutics·Eva WulstenGeoffrey Lee
Oct 5, 2010·International Journal of Pharmaceutics·Jürgen Bögelein, Geoffrey Lee
Feb 22, 2011·International Journal of Pharmaceutics·K BürkiG Betz

❮ Previous
Next ❯

Citations

Jan 31, 2016·Advanced Drug Delivery Reviews·Teófilo VasconcelosBruno Sarmento
Oct 25, 2016·International Journal of Pharmaceutics·Shuying JiMingshi Yang
Oct 4, 2020·Pharmaceutics·Melvin WostryHolger Grohganz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Related Papers

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Michael MauryGeoffrey Lee
Journal of Pharmaceutical Sciences
Hak-Kim ChanDavid Lechuga-Ballesteros
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
S SchüleW Frieb
© 2022 Meta ULC. All rights reserved