PMID: 9546423Apr 18, 1998Paper

Evaluation of SPf66 malaria vaccine efficacy in Brazil

The American Journal of Tropical Medicine and Hygiene
M UrdanetaM Boulos

Abstract

This paper reports the efficacy results of the randomized, placebo-controlled, field trial of SPf66 malaria vaccine in Costa Marques, Rondonia, Brazil. This region is characterized by the seasonal distribution of Plasmodium falciparum and P. vivax infections, and the recent occupation by migrants from nonendemic areas. A total of 800 individuals of both sexes, ranging in age from seven to 60 years, were included in the study. Of the initial cohort, 572 participants completed the vaccination schedule. Clinical and parasitologic evaluations were obtained by active and passive searches on a periodic basis. The overall protective efficacy against P. falciparum infections was -1.6% (-32.9% to 22.4%), and 14.1% (-17.0% to 36.9%) for the first episode. The overall protective efficacy for P. vivax infections was -19.7% (-44.8% to 1.03%), and -10.8% (-41.1% to 12.8%) for the first episode. No statistical evidence of an overall significant protective effect of SPf66 malaria vaccine against P. falciparum and P. vivax malaria was obtained in this trial.

Citations

Jul 20, 2007·The Cochrane Database of Systematic Reviews·P Graves, H Gelband
Sep 18, 2002·Scandinavian Journal of Immunology·L J M CarvalhoH Goto
Apr 21, 2006·The Cochrane Database of Systematic Reviews·P Graves, H Gelband
Apr 8, 2010·Expert Review of Vaccines·Aubrey J Cunnington, Eleanor M Riley
Apr 15, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Clarissa ValimDavid Wypij

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