Jan 1, 1989

Evaluation of spin labeled TEPA and CCNU analogs against osteosarcoma and MNU-induced mammary carcinoma of the SD-rat

Archiv für Geschwulstforschung
T KlennerD Schmähl

Abstract

The effectiveness to reduce tumor growth by 1-(2-chloroethyl)-3-(1-oxyl-2,2,6,6-tetramethylpiperidinyl)- 1-nitrosourea (SLCNU) and N,N,N,'N'- bis(1,2-ethanediyl)-N"-(1-oxyl-2,2,6,6-tetramethyl- 2-piperidinylaminocarbonyl)-phosphoric triamide (SLDU) was studied in osteosarcoma and MNU-induced mammary carcinoma in the SD-rat. Both compounds elicited neither an inhibitory effect on these tumors nor an increase in the mean/median life span as compared to the control group.

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Mentioned in this Paper

Antineoplastic Agents
Cyclic N-Oxides
August Rats
Malignant Bone Neoplasm
Analog
N, N, N', N'-bis(1,2-ethanediyl)-N''-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinylaminocarbonyl)phosphoric triamide
Neoplasms
Neoplasm Transplantation
Azirines
Nitrosourea Compounds

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