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Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments

BMC Bioinformatics

Feb 20, 2010

James BullardSandrine Dudoit

Abstract

High-throughput sequencing technologies, such as the Illumina Genome Analyzer, are powerful new tools for investigating a wide range of biological and medical questions. Statistical and computational methods are key for drawing meaningful and accurate conclusions from the massive and co...read more

Mentioned in this Paper

Exons
Sequence Determinations, RNA
Brain
RNA, Polyadenylated
Gene Expression
Sequencing
Genomic DNA
Genes, vif
POLR2A gene
cDNA Library
6
2345
Paper Details
References
  • References19
  • Citations551
12
  • References19
  • Citations551
12345...

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Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments

BMC Bioinformatics

Feb 20, 2010

James BullardSandrine Dudoit

PMID: 20167110

DOI: 10.1186/1471-2105-11-94

Abstract

High-throughput sequencing technologies, such as the Illumina Genome Analyzer, are powerful new tools for investigating a wide range of biological and medical questions. Statistical and computational methods are key for drawing meaningful and accurate conclusions from the massive and co...read more

Mentioned in this Paper

Exons
Sequence Determinations, RNA
Brain
RNA, Polyadenylated
Gene Expression
Sequencing
Genomic DNA
Genes, vif
POLR2A gene
cDNA Library
6
2345

Similar Papers Found In These Feeds

Structural Biology: Biophysics

Structural Biology: Biophysics describes the study of structural biology using various biophysical techiniques such as imaging, computational modeling, etc. Discover the latest research on structrual biology here.

Computation Neuroscience

Computation neuroscience employs models, statistics, simulations, and theoretical analyses to understand mechanisms that govern neural functions. Here is the latest research in this domain.

Related Papers

Nature Methods

Mapping and quantifying mammalian transcriptomes by RNA-Seq

Nature MethodsJune 3, 2008
Ali MortazaviBarbara Wold
Paper Details
References
  • References19
  • Citations551
12
  • References19
  • Citations551
12345...
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