Evaluation of Su Fu'ning Lotion's Inhibitory Effects on Bladder Cancer Cells In Vitro and In Vivo by Intravesical Instillation

Integrative Cancer Therapies
Liansheng RenJing Wang

Abstract

Bladder cancer is a common malignant tumor with a very high recurrence rate after surgery. Intravesical instillation can help clear up the residual tumor cells after surgery and thereby reduce the recurrence rate. To establish a bladder tumor transplantation animal model and to evaluate the inhibitory effects of a novel perfusate, Su Fu'ning Lotion (SFN), on bladder tumor. SFN was compared with several commonly used chemotherapy drugs, including mitomycin (MMC) and pirarubicin (THP) for anticancer effects on the bladder cancer cell lines T24, BTT, and BIU-87 and SFN half inhibitory concentrations (IC50) were determined after 48 hours of treatment. In addition, bladder cancer orthotopic transplantation tumor models were established in BALB/C nude mice and T739 mice, and SFN anticancer effects were assessed in vivo, with normal saline and MMC as negative and positive controls, respectively. SFN, MMC, and THP were all lethal to bladder cancer cells, in vitro, with SFN and THP significantly superior to MMC. IC50 values for SFN were 13.22, 11.22, and 12.5 µg/mL on T24, BTT, and BIU-87 cells, respectively. In vivo, SFN significantly reduced the mouse bladder wet weight and prolonged the animal survival compared with controls (P < .05...Continue Reading

References

Jan 1, 1992·Drug and Chemical Toxicology·C K MoonJ H Chung
Nov 26, 1999·Biochemical Pharmacology·L Y KhilC K Moon
Mar 20, 2003·Archives of Pharmacal Research·Woongchon MarEun-Kyoung Seo
May 6, 2003·European Journal of Pharmacology·Chien Ming HuYu Wen Cheng
Sep 17, 2004·Planta medica·Hyeon-Soon WonChang-Kiu Moon
Oct 12, 2004·Phytotherapy Research : PTR·Hong-Xi Xu, Song F Lee
Jul 5, 2005·Journal of Ethnopharmacology·Eun-Ju YouChang-Kiu Moon
Mar 10, 2009·World Journal of Urology·K D SievertA Stenzl
Apr 21, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Fan LiWeimin Yang
Aug 11, 2012·European Urology·Maximilian BurgerYair Lotan
Feb 15, 2013·Experimental and Therapeutic Medicine·Qinghua ZhaoJiansong Wang

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Methods Mentioned

BETA
xenografts

Software Mentioned

SPSS17
SPSS

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