Evaluation of subchronic inhalation toxicity of dimethyl disulfide in rats

Inhalation Toxicology
H Y KimJ C Kim

Abstract

This study was carried out to investigate the potential subchronic inhalation toxicity of dimethyl disulfide (DMDS) via whole-body exposure in F344 rats. Groups of 10 rats of each sex were exposed to DMDS vapor by whole-body exposure at concentrations of 0, 5, 25, or 125 ppm for 6 h/day, 5 days/wk for 13 wk. All the rats were sacrificed at the end of treatment period. During the test period, clinical signs, mortality, body weights, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross findings, organ weights, and histopathology were examined. At 25 ppm, a decrease in the body weight gain, food intake, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and blood urea nitrogen (BUN) was observed in the males, but not in the females. However, at 125 ppm, a decrease in the body weight gain, food intake, and thymus weight and an increase in the weights of adrenal glands were observed in both genders. Serum biochemical investigations revealed a decrease in the AST, ALT, BUN, creatine phosphokinase (CPK), and triglyceride levels and an increase in the glucose level. In contrast, no treatment-related effects were observed in the 5 ppm group. The toxic potency of DMDS was slightly higher in m...Continue Reading

References

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Citations

Oct 9, 2007·The Annals of Occupational Hygiene·Hyeon-Yeong KimJong-Choon Kim
Mar 23, 2011·Regulatory Toxicology and Pharmacology : RTP·Wook-Joon YuJong-Choon Kim
Jun 17, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hyeon-Yeong KimJong-Choon Kim
Jun 28, 2011·Journal of Applied Toxicology : JAT·Sung-Hwan KimJong-Choon Kim
Aug 14, 2012·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Sung-Hwan KimJong-Choon Kim
Nov 6, 2013·International Journal of Toxicology·David MorgottMarcy Banton
May 15, 2007·Environmental Toxicology·Seung-Won LeeJong-Choon Kim
Oct 20, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Y S YangJ C Kim
Jan 18, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·J C LeeJ C Kim
Feb 11, 2009·Critical Reviews in Toxicology·Anne KorpiAnna-Liisa Pasanen
Aug 18, 2010·Journal of Digital Imaging·Qi ZhangTerry M Peters
Oct 1, 2013·Molecular Informatics·Dimaitar A DobchevMati Karelson

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