Evaluation of suppressive therapy for cold thyroid nodules with levothyroxine: double-blind placebo-controlled clinical trial.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
B LarijaniM R Eshraghian

Abstract

To study the efficacy of levothyroxine suppressive therapy in the management of benign thyroid nodules. We performed a double-blind clinical trial comparing levothyroxine treatment (1.5 to 2.0 mg/kg of body weight daily) (N = 32) with placebo (N = 30) for a 1-year period in patients with a benign, cold thyroid nodule confirmed by biopsy and 99mTc-pertechnetate scanning, who were randomly assigned to the treatment or control group. High-resolution sonography was used to measure the size of the nodules before and after the treatment. Suppression of thyrotropin was evaluated by the administration of thyrotropin-releasing hormone to 10 patients randomly in each group. The mean volume of the thyroid nodules decreased significantly after 6 months in both the levothyroxine group (from 12.8 +/- 11.9 mL to 9.4 +/- 9.8 mL; P = 0.003) and the placebo group (from 13.2 +/- 10.2 mL to 11.5 +/- 8.0 mL; P = 0.003). After 12 months, however, the volume of the nodules had increased. Thus, no significant decrease was found in the mean nodule volume in either study group at 1 year in comparison with the mean volume at baseline (final mean volume: 12.4 +/- 16.7 mL in the levothyroxine group and 11.7 +/- 13.6 mL in the placebo group). Suppressive th...Continue Reading

References

Jan 1, 1977·Archives of Surgery·R D LiechtyS G Silverberg
May 11, 1976·Annals of Surgery·C G ThomasC Y Kerr
Jan 1, 1992·Clinical Endocrinology·J L ReverterA Sanmartí
Dec 1, 1988·Journal of Endocrinological Investigation·R Vigneri
Oct 6, 1986·The Medical Journal of Australia·T S ReeveP Crummer
Dec 24, 1987·The New England Journal of Medicine
Aug 15, 1985·The New England Journal of Medicine·M T Rojeski, H Gharib
Oct 1, 1974·The American Journal of Medicine·K Shimaoka, J E Sokal
Sep 1, 1982·Texas Medicine·S RubenfeldH J Spjut
Nov 1, 1980·World Journal of Surgery·M A BlockS R Kini
Jan 1, 1981·World Journal of Surgery·O H Clark
Sep 1, 1980·Indian Journal of Cancer·M M KapurA Kumar
Sep 15, 1993·Annals of Internal Medicine·S J MandelP R Larsen
Feb 15, 1993·Annals of Internal Medicine·H Gharib, J R Goellner
Feb 25, 1993·The New England Journal of Medicine·E L Mazzaferri
Mar 7, 1998·Annals of Internal Medicine·H Gharib, E L Mazzaferri
May 1, 1956·The American Journal of Medicine·S TAYLOR
Oct 1, 1960·JAMA : the Journal of the American Medical Association·E B ASTWOODG D AURBACH
Jul 1, 1960·A.M.A. Archives of Internal Medicine·R P STOFFERE N McCUSKER
Apr 6, 1963·JAMA : the Journal of the American Medical Association·J BADILLOJ E SOKAL

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Citations

Feb 3, 2000·Journal of the American College of Surgeons·P J Numann
Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Sebastiano FilettiMassimo Torlontano
Jul 11, 2014·Journal of Endocrinological Investigation·Alessandro PuzzielloMario Vitale
Sep 7, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Matthew T SdanoDavid L Steward
Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·M Regina CastroJohn C Morris
Jun 19, 2014·The Cochrane Database of Systematic Reviews·Elizabeth Bandeira-EchtlerBernd Richter
Jul 1, 2011·The Journal of Clinical Endocrinology and Metabolism·M GrussendorfUNKNOWN LISA Investigators
Jan 27, 2012·The Journal of Clinical Endocrinology and Metabolism·Emilio Fiore, Paolo Vitti
Aug 15, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Marco GalloRoberto Valcavi
Jan 30, 2004·Journal of Clinical Pharmacy and Therapeutics·B LarijaniG Maalouf

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