Evaluation of surface roughness of hydrogels by fractal texture analysis during swelling

Langmuir : the ACS Journal of Surfaces and Colloids
G MabilleauD Chappard

Abstract

The surface of a biomaterial reacts in contact with biological fluids. Hydrogels are used to prepare biomaterials. The surface roughness of materials can be explored by several techniques. However, when considering hydrogels, the surface examined in the dry state does not reflect the final conformation. How the surface roughness is affected by swelling has been little explored by quantitative methods. We have evaluated the surface roughness of poly(2-hydroxyethyl methacrylate) (i.e., pHEMA) by image analysis. Images of disks, prepared from linear pHEMA, were obtained on a light microscope after various incubation times in saline. Fractal texture analysis was done on images to determine the fractal dimension D. In this study, D exhibited a significant decrease during swelling and was highly correlated with the swelling ratio (r2 = 0.994, p < 0.00001). Water uptake by the surface of the polymer affected the surface roughness. Image analysis using fractal algorithms appears to be the most interesting technique for the quantitative exploration of surfaces of hydrated materials that cannot be measured by conventional methods.

References

Feb 1, 1990·Physics in Medicine and Biology·C B CaldwellM J Yaffe
Jan 1, 1994·Micron : the International Research and Review Journal for Microscopy·S S Cross
Jul 24, 1998·Biomaterials·C A Siedlecki, R E Marchant
Dec 30, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C S Brazel, N A Peppas
Apr 18, 2003·Biomaterials·Ging-Ho HsiueShih-Huang Lee
Feb 26, 2004·Biomaterials·Yoshihisa KanedaTadanori Mayumi
Mar 17, 2004·Biomaterials·Amedea Barozzi Seabra, Marcelo Ganzarolli De Oliveira

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Citations

Jul 18, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Mambaye N'DiayeDaniel Chappard
Sep 13, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·L Nogueiras-NietoF J Otero-Espinar
Jun 7, 2013·The Journal of Pharmacy and Pharmacology·Xianzhen YinJiwen Zhang

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