Evaluation of synthetic reticular hybrid meshes designed for intraperitoneal abdominal wall repair: Preclinical and in vitro behavior

PloS One
V Gómez-GilGemma Pascual

Abstract

Reticular hybrid meshes represent an alternative material for intraperitoneal repair of abdominal hernias. These consist of a reticular mesh coated or interwoven/knitted with inert materials. This study assesses the performance of two reticular polypropylene-containing hybrid meshes, TiMESH (coated with titanium) and DynaMesh (interwoven with polyvinylidene fluoride), in vitro, as well as their efficiency in adhesion prevention and tissue incorporation in an intraperitoneal model. The mesothelialization capacity of TiMESH and DynaMesh was evaluated in vitro and compared to that of Surgipro (reticular bare polypropylene) and Preclude (laminar expanded polytetrafluoroethylene). Mesh fragments were placed on the intact parietal peritoneum of New Zealand white rabbits (n = 24), and laparoscopy performed 7 days post-surgery. Fourteen days post-implantation, adhesions were evaluated and host tissue incorporation, macrophage response, collagen expression (immunohistochemistry/RT-PCR) and neoperitoneum formation assessed. Adhesions and omental tissue were also examined. Mesh pores in reticular meshes were devoid of cells in the in vitro study. TiMESH, DynaMesh and Surgipro showed similar adhesion rates at 7/14 days and optimal tissue i...Continue Reading

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Citations

Jul 18, 2019·Hernia : the Journal of Hernias and Abdominal Wall Surgery·M E GiménezL De Cola
Nov 23, 2019·The Journal of Surgical Research·Steven PengellySarah E Herrick
May 23, 2021·Journal of Biomedical Materials Research. Part a·Ángel Serrano-Aroca, Salvador Pous-Serrano
Jun 3, 2021·Materials·Marta RodríguezJuan Manuel Bellón

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Methods Mentioned

BETA
two hybrid
biopsies
scanning electron microscopy
dissection
electrophoresis
light microscopy

Software Mentioned

DynaMesh IPOM
DynaMesh
Image J
GraphPad Prism

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