Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection

The Journal of Infectious Diseases
Jun-ichi KawadaTsuneo Morishima

Abstract

Neonatal herpes simplex virus (HSV) infection is a severe disease with high mortality and morbidity. To investigate the pathogenesis of neonatal HSV infection, we examined inflammatory responses and markers of apoptosis in patients with neonatal HSV infection. Concentrations of inflammatory cytokines and markers of apoptosis were significantly higher in patients with disseminated HSV infection and were correlated with HSV load. It appears that the immunopathological damage that results from host responses to viral infection leads to organ dysfunction in patients with neonatal HSV infection.

Citations

Aug 4, 2005·Virology Journal·Svend Ellermann-Eriksen
Nov 26, 2009·Uirusu·Tsuneo Morishima
Jun 6, 2013·Clinical & Developmental Immunology·Emilie Tourneur, Cecilia Chassin
Feb 6, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·A MejíasP J Sánchez
Jan 13, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Tsunehisa NagamoriHiroshi Azuma
Jun 24, 2010·Clinics in Perinatology·James L Wynn, Hector R Wong
Oct 25, 2007·Gynecologic and Obstetric Investigation·Jian-Ping ZhangXin-Wen Zhang
Jan 19, 2006·Journal of Medical Virology·Jun-Ichi KawadaTsuneo Morishima
Sep 25, 2019·International Journal of Hematology·Motoshi SonodaShouichi Ohga
Mar 5, 2019·The Tohoku Journal of Experimental Medicine·Hiroki TakeharaNaoto Takahashi

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