Evaluation of T cell cytokines and their role in recurrent miscarriage

International Immunopharmacology
Shafat AliShahnaz Taing

Abstract

Recurrent miscarriage (RM) is defined as two or more consecutive pregnancy losses that affect approximately 5% of conceived women worldwide. RM is a multi-factorial reproductive problem and has been associated with parental chromosomal abnormalities, embryonic chromosomal rearrangements, uterine anomalies, autoimmune disorders, endocrine dysfunction, thrombophilia, life style factors, and maternal infections. However, the exact cause is still undecided in remaining 50% of cases. Immunological rejection of the embryo due to exacerbated maternal immune reaction against paternal embryonic antigens has been set forth as one of the significant reason for RM. The accurate means that shield the embryo during normal pregnancy from the attack of maternal immune network and dismissal are inadequately implicit. However, it is suggested that the genetically irreconcilable embryo escapes maternal immune rejection due to communication among many vital cytokines exuded at maternal-embryonic interface both by maternal and embryonic cells. Previous investigations suggested the Th1/Th2 dominance in altered immunity of RM patients, according to which the allogenic embryo flees maternal T cell reaction by inclining the Th0 differentiation toward T...Continue Reading

Citations

Feb 6, 2021·Journal of Reproductive Immunology·Sanja LöbTheresa Vilsmaier
May 3, 2021·American Journal of Reproductive Immunology : AJRI·Theresa VilsmaierThomas Kolben
Jun 17, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Yihong ChenShan Zheng
Oct 1, 2020·Saudi Journal of Biological Sciences·Shafat AliFahad A Al-Misned

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