Evaluation of target dose inhomogeneity in breast cancer treatment due to tissue elemental differences

Radiation Oncology
Antonella FogliataLuca Cozzi

Abstract

Monte Carlo simulations were run to estimate the dose variations generated by thedifference arising from the chemical composition of the tissues. CT datasets of five breast cancer patients were selected. Mammary gland was delineated as clinical target volume CTV, as well as CTV_lob and CTV_fat, being the lobular and fat fractions of the entire mammary gland. Patients were planned for volumetric modulated arc therapy technique, optimized in the Varian Eclipse treatment planning system. CT, structures and plans were imported in PRIMO, based on Monte Carlo code Penelope, to run three simulations: AdiMus, where the adipose and muscle tissues were automatically assigned to fat and lobular fractions of the breast; Adi and Mus, where adipose and muscle, respectively were assigned to the whole mammary gland. The specific tissue density was kept identical from the CT dataset. Differences in mean doses in the CTV_lob and CTV_fat structures were evaluated for the different tissue assignments. Differences generated by the tissue composition and estimated by Acuros dose calculations in Eclipse were also analysed. From Monte Carlo simulations, the dose in the lobular fraction of the breast, when adipose tissue is assigned in place of muscle,...Continue Reading

References

Jun 3, 1998·Medical Physics·D A LowJ A Purdy
Dec 3, 2002·International Journal of Radiation Oncology, Biology, Physics·Frank A ViciniJohn Wong
Jun 28, 2008·Physics in Medicine and Biology·L TillikainenW Ulmer
Jan 9, 2010·Physics in Medicine and Biology·Oleg N VassilievFiras Mourtada
Feb 12, 2010·The New England Journal of Medicine·Timothy J WhelanCarolyn Freeman
Sep 6, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M RodriguezL Brualla
May 29, 2014·International Journal of Radiation Oncology, Biology, Physics·Etin-Osa O OsaSilvia C Formenti
Aug 3, 2014·International Journal of Radiation Oncology, Biology, Physics·Kimberley S MakJennifer R Bellon
Mar 31, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Icro MeattiniLorenzo Livi

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Citations

Sep 4, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Marciana Nona DumaAndrea Wittig

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Software Mentioned

PRIMO
Acuros XB
Geant4
Acuros
AdiMus
Eclipse
Varian Eclipse
Mus
PENELOPE
AAA

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