Evaluation of telomere length maintenance mechanisms in adrenocortical carcinoma

The Journal of Clinical Endocrinology and Metabolism
Tobias ElseGary D Hammer

Abstract

Adrenocortical cancer (ACC) is a rare disease with an often fatal outcome. The clinical and pathological diagnosis of a malignant vs. benign adrenocortical tumor is sometimes challenging. Telomere maintenance mechanisms (TMMs) are critical for the persistence of the malignant phenotype, but little is known about these mechanisms or their diagnostic value in adrenocortical lesions. Tissue samples of diagnostically known adrenocortical neoplasms were evaluated for parameters of known TMMs, telomerase activity (TA), and alternative telomere lengthening (ALT). The study analyzed retrospectively collected frozen adrenocortical tissue samples from the University of Michigan Health System. Samples included 24 ACCs, 11 adrenocortical adenomas (ACAs), and three normal adrenal tissues. Telomerase activity (telomerase activity protocol assay), alternative telomere lengthening (telomere restriction fragment analysis, telomere associated promyelocyte leukemia bodies) were measured. A total of 22 of 24 ACCs (92%) could be definitively assigned to a TMM. The TMM classification was: 19 of 24 TA (79%), two of which displayed very long telomeres, one of 24 ALT (4%) and two of 24 (8%) TA and ALT. Results of two of 24 (8%) were inconclusive (one n...Continue Reading

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