Evaluation of the Acceleration and Deceleration Phase-Rectified Slope to Detect and Improve IUGR Clinical Management

Computational and Mathematical Methods in Medicine
S TagliaferriPasquale Martinelli

Abstract

This study used a new method called Acceleration (or Deceleration) Phase-Rectified Slope, APRS (or DPRS) to analyze computerized Cardiotocographic (cCTG) traces in intrauterine growth restriction (IUGR), in order to calculate acceleration- and deceleration-related fluctuations of the fetal heart rate, and to enhance the prediction of neonatal outcome. Cardiotocograms from a population of 59 healthy and 61 IUGR fetuses from the 30th gestation week matched for gestational age were included. APRS and DPRS analysis was compared to the standard linear and nonlinear cCTG parameters. Statistical analysis was performed through the t-test, ANOVA test, Pearson correlation test and receiver operator characteristic (ROC) curves (p < 0, 05). APRS and DPRS showed high performance to discriminate between Healthy and IUGR fetuses, according to gestational week. A linear correlation with the fetal pH at birth was found in IUGR. The area under the ROC curve was 0.865 for APRS and 0.900 for DPRS before the 34th gestation week. APRS and DPRS could be useful in the identification and management of IUGR fetuses and in the prediction of the neonatal outcome, especially before the 34th week of gestation.

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Citations

May 18, 2019·The Journal of Obstetrics and Gynaecology Research·Francesca G EspositoFulvio Zullo
Oct 18, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Hongyun LiuLuming Li
Jan 17, 2021·American Journal of Obstetrics & Gynecology MFM·Gabriele SacconeFulvio Zullo
Sep 3, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Salvatore TagliaferriMarta Campanile

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Methods Mentioned

BETA
Cesarean section

Software Mentioned

TRUFFLE
ApEn
APRS
SPSS
DPRS

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