Evaluation of the anti-inflammatory effects of ellagic acid

Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses
Stephanie CorbettNormalynn Garrett

Abstract

Few studies have investigated the anti-inflammatory properties of ellagic acid and no published studies have examined the effects of ellagic acid in combination with anesthetic adjuvants. In this study, 54 Sprague-Dawley rats were assigned to one of six groups: (1) vehicle; (2) ketorolac and vehicle; (3) meloxicam and vehicle; (4) ellagic acid and vehicle; (5) ellagic acid, ketorolac, and vehicle; and (6) ellagic acid, meloxicam, and vehicle. Groups 5 and 6 investigated interactions between ellagic acid and cyclooxygenase inhibitors. Paw inflammation was induced with 3% carrageenan and was measured with a plethysmometer at 30 minutes and 4, 8, and 24 hours after intraperitoneal injection. All rats received one intraperitoneal injection of equivalent volumes according to group assignment. Analysis of covariance followed by post hoc analysis determined that ketorolac was the only compound to significantly reduce paw edema at 4 hours (P = .019); ellagic acid alone (P = .038) and the combination of ellagic acid and ketorolac (P = .038) were the only compounds to significantly reduce paw edema at 8 hours. At 24 hours, only ellagic acid was effective (P = .01). Our findings suggest that ellagic acid may be effective against inflammat...Continue Reading

References

Apr 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R W Teel, R M Martin
Nov 20, 1998·JAMA : the Journal of the American Medical Association·D M EisenbergR C Kessler
Jun 25, 2002·The Journal of Pharmacy and Pharmacology·Gabriela Egly FeresinGuillermo Schmeda-Hirschmann
Sep 18, 2003·JAMA : the Journal of the American Medical Association·John S MarkowitzKenneth D Chavin
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Farrukh AfaqHasan Mukhtar
Oct 27, 2004·Paediatric Anaesthesia·Suzanne Crowe, Barry Lyons
Jun 1, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sushma M BhosleKaushala Prasad Mishra
Mar 28, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marcella MartignoniRuben de Kanter
Sep 2, 2006·The Journal of Pharmacy and Pharmacology·Alexandre P RogerioLúcia H Faccioli
Sep 28, 2006·Methods and Findings in Experimental and Clinical Pharmacology·J A O Ojewole
Dec 10, 2009·Nature Reviews. Urology·Greg TrottierNeil E Fleshner

❮ Previous
Next ❯

Citations

Mar 27, 2013·European Journal of Pharmacology·Mohammad Taghi MansouriYaghoub Farbood
Aug 7, 2014·Indian Journal of Pharmacology·Mohammad Taghi MansouriBehnam Ghorbanzadeh
Jun 9, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Maria Angeles RosilloCatalina Alarcón de la Lastra
Jan 1, 2014·Mediators of Inflammation·Claudiney de Freitas AlvesAlexandre de Paula Rogerio
Nov 9, 2011·The Biochemical Journal·Puppala MuthennaG Bhanuprakash Reddy
Jun 1, 2014·Chemico-biological Interactions·Amjid AhadWaseem Ahmad Siddiqui
May 6, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wylly Ramsés García-Niño, Cecilia Zazueta
Sep 3, 2014·European Journal of Pharmacology·Mohammad Taghi MansouriBehnam Ghorbanzadeh
Feb 24, 2016·Food & Function·G RaghuG Bhanuprakash Reddy
Jan 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jaemin LeeKi Sung Kang
Apr 3, 2018·Journal of Food Science and Technology·Pao-Ju LeeShaun Chen
Oct 13, 2012·Food & Function·Svjetlana Medjakovic, Alois Jungbauer
May 25, 2013·International Journal of Food Sciences and Nutrition·Coskun UstaPaolo Emilio Puddu
Dec 2, 2019·GeroScience·Priyanka KharatKavitha Thirumurugan
Oct 6, 2020·Advances in Pharmacological and Pharmaceutical Sciences·Stephanie Flore Djuichou NguemnangEgbe Ben Besong
Feb 4, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Narin KakatumArunporn Itharat
Dec 29, 2020·Phytotherapy Research : PTR·Venkatasubramanian AishwaryaVenkatabalasubramanian Sivaramakrishnan
Dec 17, 2020·Pharmaceutics·Marismar F do NascimentoRicardo L C de Albuquerque-Junior

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here