Evaluation of the anti-inflammatory properties of Dodonaea polyandra, a Kaanju traditional medicine

Journal of Ethnopharmacology
Bradley S SimpsonSusan J Semple

Abstract

Extracts of the medicinal plant species Dodonaea polyandra were investigated as part of a collegial research partnership between Northern Kaanju traditional owners represented by Chuulangun Aboriginal Corporation (centred on the Wenlock and Pascoe Rivers, Cape York Peninsula, Queensland, Australia) and university-based researchers. D. polyandra, known as "Uncha" in Kaanju language, is used in Northern Kaanju Traditional Medicine for relief from pain associated with toothache and related ailments. The species has a restricted distribution in Cape York Peninsula and there has been no previous Western scientific investigation of its pharmacology or chemistry. The current study investigates the anti-inflammatory effects of several extracts from D. polyandra. Phytochemical screening was conducted using TLC. Anti-inflammatory effects of leaf extracts were determined using an acute mouse ear oedema model induced by croton oil and 12-o-tetradecanoylphorbol-13-acetate (TPA) chemical irritants. Flavonoid and terpenoid secondary compounds were detected in leaf extracts of D. polyandra. Non-polar hexane and methylene chloride/methanol extracts showed potent inhibition of inflammation in TPA-induced mouse ear oedema by 72.12 and 79.81%, res...Continue Reading

References

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Citations

Mar 9, 2011·Journal of Natural Products·Bradley S SimpsonSusan J Semple
Feb 4, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Hsueh-Ling ChengChang-Hung Chou
Nov 22, 2013·Pharmaceutical Biology·Xi ChenYan Zhang
Aug 23, 2012·Phytochemistry·Bradley S SimpsonSusan J Semple
Jun 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·David Osvaldo Salinas-SánchezMaribel Herrera-Ruiz
Dec 6, 2017·Asian Pacific Journal of Tropical Medicine·Claudia V Moreno-QuirósRosa V García-Rodríguez
Nov 14, 2020·Neurochemistry International·Ahilya SinghGerald Münch

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