Evaluation of the anti-Leishmania activity of ethanol extract and fractions of the leaves from Pityrogramma calomelanos (L.) link

Natural Product Research
Teógenes M SouzaHenrique D M Coutinho

Abstract

Leishmaniasis is caused by parasites of the genus Leishmania. Recent reports about leishmaniasis show a few number of drugs available, indicating the necessity of new drugs. In this study, the ethanol extract and fractions of Pityrogramma calomelanos (L.) link. (Pteridaceae) were assayed to verify the cytotoxicity and in vitro leishmanicidal activity against promastigote forms of Leishmania brasiliensis. The cytotoxic assay was performed using fibroblasts NCTC929. The studies indicated a leishmanicidal effect of the ethanol extract and the ethyl-acetate fraction. However, a high cytotoxic effect was observed. The hexane and methanol fractions did not show leishmanicidal activity, nor cytotoxic effect. The phytochemical screening detected the presence of alkaloids, a class of secondary metabolites with a known leishmanicidal activity. This is the first study reporting an anti-Leishmania and cytotoxic effect of P. calomelanos, being an interesting approach in the search for drugs against this disease.

References

Apr 1, 1996·Journal of Natural Products·E F QueirozA Fournet
Jun 17, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A G TemponeD C H Fischer
Jul 13, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L G RochaJ M Barbosa-Filho
Sep 10, 2005·Trends in Parasitology·Simon L CroftJulio A Urbina
Nov 23, 2005·Trends in Parasitology·Jean-Claude Dujardin
Jan 19, 2006·Clinical Microbiology Reviews·Simon L CroftAlan H Fairlamb
Jul 18, 2006·International Journal of Antimicrobial Agents·Miriam RolónFrancisco Malpartida
Feb 24, 2007·Journal of Ethnopharmacology·P J HoughtonG Steventon
Sep 18, 2008·Memórias do Instituto Oswaldo Cruz·Ricardo Reyes-ChilpaSimón Hernández-Ortega

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Citations

Oct 6, 2016·Phytotherapy Research : PTR·Nazif UllahMuhammad Hamayun
Nov 3, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberta K F MarraVeronica F Amaral
Jan 1, 2017·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Hui CaoHenrique D M Coutinho

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