Jan 1, 1975

Evaluation of the antibiotic effect of treatment of maxillary sinusitis

Scandinavian Journal of Infectious Diseases
C CarenfeltB Wretlind

Abstract

As the effect of antibiotic treatment of maxillary sinusitis has been questioned, the elimination of bacteria from sinus secretions was studied during antibiotic treatment. Penicillin V, azidocillin, tetracycline or doxycycline was administered to 54 patients with maxillary sinusitis. Samples of sinus secretion were aspirated both before treatment and 2-3 days after the onset of treatment. When the antibiotic concentration was below the upper limit of MIC for sensitivity group 1, bacterial growth was present in practically all samples. When the antibiotic concentration equalled or was above this limit, there was no bacterial growth in about half of the samples. A prerequisite for antibiotic effect--elimination of bacteria--is that the antibiotic concentration is well above the MIC of the bacteria at the site of infection. The choice between bactericidal or bacteriostatic antibiotics appeared unimportant. Bacterial survival in the maxillary sinus despite a high antibiotic concentration in the sinus illustrates that MIC values determined in the laboratory do not always mirror the sensitivity of bacteria to antibiotics in vivo.

  • References10
  • Citations12

Citations

Mentioned in this Paper

Tetracycline Antibiotics
Tetracyclines
Doxycycline Phosphate (1: 1)
Doxycycline
Entire Maxillary Sinus
Haemophilus influenzae
Antibiotic throat preparations
Antifungal Antibiotics, Topical
Chronic Maxillary Sinusitis
Streptococcus

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