Evaluation of the antidiarrhoeal activity of the hydroethanolic leaf extract of Pupalia lappacea Linn. Juss. (Amaranthaceae)

Journal of Ethnopharmacology
Abidemi J AkindeleU V Ohonbamu

Abstract

Pupalia lappacea is a medicinal plant found in savannah and woodland localities and forest path sides from Senegal to Southern Nigeria. It has been used in the management of diarrhoea in Nigerian traditional medicine. This study was designed to evaluate the antidiarrhoeal activity of the hydroethanolic leaf extract of Pupalia lappacea (PL). The antidiarrhoeal activity of PL was evaluated using the normal and castor oil-induced intestinal transit, castor oil-induced diarrhoea, gastric emptying and intestinal fluid accumulation tests in rodents. PL (100-400mg/kg, p.o.) produced a significant dose-dependent decrease in normal and castor oil-induced intestinal transit compared with the control group (distilled water 10ml/kg, p.o.). This effect was significantly (P<0.05) inhibited by pilocarpine (1mg/kg, s.c.) but not by yohimbine (10mg/kg, s.c.), prazosin (1mg/kg, s.c.), or propranolol (1mg/kg, i.p.). The extract produced a dose-dependent and significant increase in the onset of diarrhoea. PL (100-400mg/kg) also reduced the diarrhoea score, number and weight of wet stools. The in-vivo antidiarrhoeal index (ADIin vivo) of 56.95% produced by the extract at the dose of 400mg/kg was lower compared to that produced by loperamide 5mg/kg ...Continue Reading

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Citations

Jan 19, 2016·BioMed Research International·Patrick Valere Tsouh FokouFabrice Fekam Boyom
Oct 31, 2015·Journal of Ethnopharmacology·Olanrewaju A SalakoOlufunmilayo O Adeyemi
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zaineb Ben BarkaOlfa Tebourbi
Jun 3, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Mulugeta MollaSolomon M Abay
Aug 12, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Jiankang YuZhongqiong Yin
Aug 21, 2021·Drug Metabolism and Personalized Therapy·Murtala Akanji AbdullahiWasiu Eniola Olooto
Mar 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rui XiongChangjiang Hu

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